Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
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- Robin Terrisse, Dimitrios Tsimpis, Catherine A. Whiting. D-branes and non-Abelian T-duality. Nuclear Physics B, 2019, 947, pp.114733. ⟨10.1016/j.nuclphysb.2019.114733⟩. ⟨hal-01937916⟩
- Emmanuelle Couty, Alexis Vallard, Sandrine Sotton, Sarra Ouni, Max-Adrien Garcia, et al.. Safety assessment of anticancer drugs in association with radiotherapy in metastatic malignant melanoma: a real-life report. Cancer Chemother.Pharmacol., 2019, 83 (5), pp.881-892. ⟨10.1007/s00280-019-03806-5⟩. ⟨hal-02557733⟩
- Mira Maalouf, Adeline Granzotto, Clément Devic, Larry Bodgi, Mélanie Ferlazzo, et al.. Influence of Linear Energy Transfer on the Nucleo-shuttling of the ATM Protein: A Novel Biological Interpretation Relevant for Particles and Radiation. International Journal of Radiation Oncology, Biology, Physics, 2019, 103 (3), pp.709-718. ⟨10.1016/j.ijrobp.2018.10.011⟩. ⟨hal-02081379⟩
- Giacomo Cacciapaglia, Gabriele Ferretti, Thomas Flacke, Hugo Serôdio. Light scalars in composite Higgs models. Front.in Phys., 2019, 7, pp.22. ⟨10.3389/fphy.2019.00022⟩. ⟨hal-02058552⟩
- Chengfeng Cai, Giacomo Cacciapaglia, Hong-Hao Zhang. Vacuum alignment in a composite 2HDM. Journal of High Energy Physics, 2019, 01, pp.130. ⟨10.1007/JHEP01(2019)130⟩. ⟨hal-01815111⟩
- Michael Bender, Nicolas Schunck, Jean-Paul Ebran, Thomas Duguet. Single-Reference and Multi-Reference Formulation. Nicolas Schunck. Energy Density Functional Methods for Atomic Nuclei, IOP Publishing, pp.3-1-3-78, 2019, ⟨10.1088/2053-2563/aae0edch1⟩. ⟨hal-02883938⟩
- Giacomo Cacciapaglia, Alexandra Carvalho, Aldo Deandrea, Thomas Flacke, Benjamin Fuks, et al.. Next-to-leading-order predictions for single vector-like quark production at the LHC. Physics Letters B, 2019, 793, pp.206-211. ⟨10.1016/j.physletb.2019.04.056⟩. ⟨hal-01937776⟩
- Sabine Harribey, Dimitrios Tsimpis. One-loop bosonic string and De Sitter space. Nuclear Physics B, 2019, 948, pp.114768. ⟨10.1016/j.nuclphysb.2019.114768⟩. ⟨hal-01897220⟩
- C. Aidala, Y. Akiba, M. Alfred, V. Andrieux, N. Apadula, et al.. Nonperturbative transverse momentum broadening in dihadron angular correlations in
GeV proton-nucleus collisions. Phys.Rev.C, 2019, 99 (4), pp.044912. ⟨10.1103/PhysRevC.99.044912⟩. ⟨hal-01890811⟩ - David Sarrut, Nils Krah, Jean-Michel Létang. Generative adversarial networks (GAN) for compact beam source modelling in Monte Carlo simulations. Physics in Medicine and Biology, 2019, 64 (21), ⟨10.1088/1361-6560/ab3fc1⟩. ⟨hal-02276243⟩
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