Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. One-dimensional charged kaon femtoscopy in p-Pb collisions at \sqrt{s_{\rm NN}} = 5.02 TeV. Physical Review C, 2019, 100 (2), pp.024002. ⟨10.1103/PhysRevC.100.024002⟩. ⟨hal-02101682⟩
    • Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. Charged-particle production as a function of multiplicity and transverse spherocity in pp collisions at \sqrt{s} =5.02 and 13 TeV. European Physical Journal C: Particles and Fields, 2019, 79 (10), pp.857. ⟨10.1140/epjc/s10052-019-7350-y⟩. ⟨hal-02148291⟩
    • Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. Measurement of \Upsilon(1{\rm S}) elliptic flow at forward rapidity in Pb-Pb collisions at \sqrt{s_{\rm{NN}}}=5.02 TeV. Physical Review Letters, 2019, 123 (19), pp.192301. ⟨10.1103/PhysRevLett.123.192301⟩. ⟨hal-02193942⟩
    • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. p-p, p-\Lambda and \Lambda-\Lambda correlations studied via femtoscopy in pp reactions at \sqrt{s} = 7 TeV. Physical Review C, 2019, 99 (2), pp.024001. ⟨10.1103/PhysRevC.99.024001⟩. ⟨hal-01815196⟩
    • Alexandra Dupuy, Helene M. Courtois, Florent Dupont, Florence Denis, Romain Graziani, et al.. Partitioning the universe into gravitational basins using the cosmic velocity field. Monthly Notices of the Royal Astronomical Society, 2019, 489 (1), pp.L1-L6. ⟨10.1093/mnrasl/slz115⟩. ⟨hal-02279100⟩
    • Young-Lo Kim, Yijung Kang, Young-Wook Lee. Environmental Dependence of Type Ia Supernova Luminosities from the YONSEI Supernova Catalog. J.Korean Astron.Soc., 2019, 52 (5), pp.181-205. ⟨10.5303/JKAS.2019.52.5.181⟩. ⟨hal-02309059⟩
    • S. Biswas, A. Lemasson, M. Rejmund, A. Navin, Y.H. Kim, et al.. Effects of one valence proton on seniority and angular momentum of neutrons in neutron-rich ^{122-131}Sb_{51} isotopes. Physical Review C, 2019, 99 (6), pp.064302. ⟨10.1103/physrevc.99.064302⟩. ⟨hal-02154730⟩
    • A. Phipps, A. Juillard, B. Sadoulet, B. Serfass, Y. Jin. A HEMT-Based Cryogenic Charge Amplifier with sub-100 eVee Ionization Resolution for Massive Semiconductor Dark Matter Detectors. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2019, 940, pp.181-184. ⟨10.1016/j.nima.2019.06.022⟩. ⟨hal-02171520⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for dark matter in events with a leptoquark and missing transverse momentum in proton-proton collisions at 13 TeV. Phys.Lett.B, 2019, 795, pp.76-99. ⟨10.1016/j.physletb.2019.05.046⟩. ⟨hal-01953194⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Pseudorapidity distributions of charged hadrons in xenon-xenon collisions at \sqrt{s_\mathrm{NN}} = 5.44 TeV. Phys.Lett.B, 2019, 799, pp.135049. ⟨10.1016/j.physletb.2019.135049⟩. ⟨hal-02051551⟩

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