Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M. Acciarri, O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, et al.. Measurement of the Effective Weak Mixing Angle by Jet-Charge Asymmetry in Hadronic Decays of the Z Boson. Physics Letters B, 1998, 439, pp.225-236. ⟨10.1016/S0370-2693(98)01174-5⟩. ⟨in2p3-00000054⟩
  • M. Kibler, G.-H. Lamot, P. Winternitz. Classical Trajectories for two Ring-Shaped Potentials. International Journal of Quantum Chemistry, 1998, 43, pp.625-645. ⟨10.1002/qua.560430503⟩. ⟨in2p3-00115760⟩
  • P. Abreu, W. Adam, T. Adye, P. Adzic, I. Ajinenko, et al.. Measurement of the W-pair cross-section and of the W mass in e^+ e^- interactions at 172 GeV. European Physical Journal C: Particles and Fields, 1998, 2, pp.581-595. ⟨10.1007/s100520050163⟩. ⟨in2p3-00001113⟩
  • M. Kaci, M.G. Porquet, Ch. Vieu, C. Schuck, A. Astier, et al.. Spin and parity values of states of dipole bands in ^{194}Pb. The European physical journal. A, Hadrons and Nuclei, 1998, 3, pp.201-203. ⟨10.1007/s100500050167⟩. ⟨in2p3-00005054⟩
  • M. Acciarri, O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, et al.. Angular multiplicity fluctuations in hadronic Z decays and comparison to QCD models and analytical calculations. Physics Letters B, 1998, 428, pp.186-196. ⟨10.1016/S0370-2693(98)00386-4⟩. ⟨in2p3-00000013⟩
  • E. Galichet, F. Gulminelli, D. Guinet, M. Assenard, G. Auger, et al.. Comparison between data measured by INDRA and the prediction of the BNV transport model for ^{36}Ar +^{58}Ni reaction at 95 A MeV. International Winter Meeting on nuclear Physics 36, 1998, Bormio, Italy. pp.410-424. ⟨in2p3-00003253⟩
  • M. Acciarri, O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, et al.. Study of the Hadronic Photon Structure Function F^\gamma_2 at LEP. Physics Letters B, 1998, 436, pp.403-416. ⟨10.1016/S0370-2693(98)01025-9⟩. ⟨in2p3-00000021⟩
  • P. Abreu, W. Adam, T. Adye, P. Adzic, I. Ajinenko, et al.. First evidence for a charm radial excitation, D^{\star}'. Physics Letters B, 1998, 426, pp.231-242. ⟨10.1016/S0370-2693(98)00346-3⟩. ⟨in2p3-00003431⟩
  • P. Abreu, W. Adam, T. Adye, P. Adzic, G D. Alekseev, et al.. Measurement of Trilinear Gauge Couplings in e^+ e^- Collisions at 161 GeV and 172 GeV. Physics Letters B, 1998, 423, pp.194-206. ⟨10.1016/S0370-2693(98)00080-X⟩. ⟨in2p3-00001109⟩
  • H. Langevin-Joliot, J. van de Wiele, F. Jourdan, J. Guillot, E. Gerlic, et al.. Valence and inner hole responses via the ^{208}Pb(\overrightarrow{d},t)^{207}Pb reaction atE_{d}=200 MeV and form factor dependence. Physical Review C, 1998, 58, pp.2192-2204. ⟨in2p3-00003436⟩

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