Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • X. Artru. Comparison of parametric X rays and diffracted transition radiation in perfect and mosaic crystals. International Workshop on Radiation Physics with Relativistic Electron, 1998, Tabarz, Germany. ⟨in2p3-00003857⟩
  • G. Chanfray, J. Delorme, M. Ericson. Chiral Symmetry Restoration in nuclei and Parity Mixing. Nuclear Physics A, 1998, 637, pp.421-432. ⟨10.1016/S0375-9474(98)00237-1⟩. ⟨in2p3-00003398⟩
  • Y. Déclais. La masse du neutrino. Pour la science, 1998, 249, pp.25. ⟨in2p3-00007673⟩
  • M. Daoud, Y. Hassouni, M. Kibler. On Generalized Super-Coherent States. 1998, pp.9. ⟨in2p3-00005628⟩
  • P. Schuurmans, B. Will, I. Berkes, J. Camps, M. de Jésus, et al.. Alpha-particle angular distributions of At and Rn isotopes and their relation to nuclear structure. Physical Review Letters, 1998, 77, pp.4720-4723. ⟨in2p3-00007520⟩
  • S. Bouneau, F. Azaiez, J. Duprat, I. Deloncle, M.G. Porquet, et al.. Decay from superdeformed yrast states to normal deformed states in ^{193}Tl. The European physical journal. A, Hadrons and Nuclei, 1998, 2, pp.245-248. ⟨in2p3-00005044⟩
  • S. Pécourt, B. Chambon, M. de Jésus, D. Drain, G. Gerbier, et al.. Calibration of a CsI(Tl) crystal with nuclear recoils and pulse shape measurements for dark matter detection. Astroparticle Physics, 1998, 11, pp.457-462. ⟨in2p3-00005041⟩
  • V.N. Baier, T.V. Dimova, V.P. Druzhinin, M.S. Dubrovin, V.B. Golubev, et al.. Set-up optimization for an experimental test of a positron source using channeling. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1998, 145, pp.221-229. ⟨in2p3-00003426⟩
  • M. Acciarri, O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, et al.. Production of Single W Bosons in e^+ e^- Interactions at 130 \leq \sqrt{s} \leq 183 GeV and Limits on Anomalous WW\gamma Couplings. Physics Letters B, 1998, 436, pp.417-427. ⟨in2p3-00023168⟩
  • M C. Abreu, J. Astruc, C. Baglin, A. Baldit, M. Bedjidian, et al.. Transverse momentum of J/\psi,\psi' and mass continuum muon pairs produced in ^{32}S-U collisions at 200 GeV/c per nucleon. Physics Letters B, 1998, 423, pp.207-212. ⟨10.1016/S0370-2693(98)00088-4⟩. ⟨in2p3-00005042⟩

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