Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M. Acciarri, O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, et al.. Upper Limit on the Lifetime Difference of Short- and Long-lived B^0_s Mesons. Physics Letters B, 1998, 438, pp.417-429. ⟨10.1016/S0370-2693(98)01114-9⟩. ⟨in2p3-00000024⟩
  • M. Acciarri, O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, et al.. Measurement of the Effective Weak Mixing Angle by Jet-Charge Asymmetry in Hadronic Decays of the Z Boson. Physics Letters B, 1998, 439, pp.225-236. ⟨10.1016/S0370-2693(98)01174-5⟩. ⟨in2p3-00000054⟩
  • E. Galichet, F. Gulminelli, D. Guinet, M. Assenard, G. Auger, et al.. Comparison between data measured by INDRA and the prediction of the BNV transport model for ^{36}Ar +^{58}Ni reaction at 95 A MeV. International Winter Meeting on nuclear Physics 36, 1998, Bormio, Italy. pp.410-424. ⟨in2p3-00003253⟩
  • A. Duperrin. Measurement of the W mass in WW \to q \overline{q}q \overline{q} at 183 GeV with neural network. 1998, pp.13. ⟨in2p3-00002392⟩
  • M. Daoud, Y. Hassouni, M. Kibler. Generalized supercoherent states. Yadernaya Fizika, 1998, 61, pp.1935-1938. ⟨in2p3-00003692⟩
  • M. Ericson, S. Kulagin, M. Rosa-Clot. Pion and the enhancement factor in the photoabsorption sum rule. Il Nuovo Cimento A, 1998, 111, pp.75. ⟨in2p3-00003786⟩
  • X. Artru. Comparison of parametric X rays and diffracted transition radiation in perfect and mosaic crystals. International Workshop on Radiation Physics with Relativistic Electron, 1998, Tabarz, Germany. ⟨in2p3-00003857⟩
  • R. Grzywacz, J.M. Daugas, N.L. Achouri, J.C. Angélique, D. Baiborodin, et al.. Microsecond isomers beyond ^{68}Ni. Conference on Nuclear Structure 98, 1998, Gatlinburg, United States. pp.257-263, ⟨10.1063/1.59553⟩. ⟨in2p3-00023061⟩
  • J.M. Daugas, M. Lewitowicz, R. Anne, J.C. Angélique, L. Axelsson, et al.. Interplay between nuclear structure and reaction mechanism in the production of projectile-like short-lived isomers. ENAM 98 Exotic Nuclei and Atomic Masses, 1998, Bellaire, United States. pp.494-497, ⟨10.1063/1.57248⟩. ⟨in2p3-00003091⟩
  • M. Daoud, Y. Hassouni, M. Kibler. On Generalized Super-Coherent States. 1998, pp.9. ⟨in2p3-00005628⟩

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