Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • G. Chanfray. Chiral symmetry restoration and dense matter. Journees d'Etudes SATURNE, Feb 1998, Ramatuelle, France. ⟨in2p3-00004566⟩
  • D. Dore, B. Borderie, G. Auger, M. Assenard, E. Galichet, et al.. Quasi-projectile and mid-rapidity characteristics in the ^{36}Ar+^{58}Ni reaction at 95A MeV. International Winter Meeting on Nuclear Physics 36, Jan 1998, Bormio, Italy. pp.381-394. ⟨in2p3-00002937⟩
  • M C. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, J. Astruc, et al.. Anomalous J/\psi suppression in Pb-Pb collisions. International Winter Meeting on Nuclear Physics 36, Jan 1998, Bormio, Italy. pp.182-189. ⟨in2p3-00002920⟩
  • S. Perriès, A. Astier, L. Ducroux, M. Meyer, N. Redon, et al.. Decay-out of the yrast highly-deformed band in ^{136}Nd : towards an experimental extraction of the neutron pairing gap in the second well. International Winter Meeting on Nuclear Physics 36, Jan 1998, Bormio, Italy. pp.112-116. ⟨in2p3-00005051⟩
  • M C. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, J. Astruc, et al.. A possible evidence of Coulomb fission in Pb-Pb interactions at 158 AGeV. International Winter Meeting on Nuclear Physics 36, Jan 1998, Bormio, Italy. pp.190-201. ⟨in2p3-00002923⟩
  • D. Cussol, J. Peter, D. Dore, G. Auger, M. Assenard, et al.. Chemical and kinematical properties of mid-rapidity emissions in Ar+Ni collisions from 52 to 95 A.MeV. International Winter Meeting on Nuclear Physics 36, Jan 1998, Bormio, Italy. pp.395-409. ⟨in2p3-00003707⟩
  • F. Goldenbaum, M. Chevallier, C. Cohen, D. Dauvergne, J. Dural, et al.. Direct fission lifetime measurements as a function of temperature and fission charge asymmetry. International Winter Meeting on Nuclear Physics 36, Jan 1998, Bormio, Italy. pp.265-276. ⟨in2p3-00002926⟩
  • P. Schuck, F. Bonutti, G. Chanfray, E. Fragiacomo, N. Grion, et al.. In-medium \pi-\pi correlations in the \rho-meson-channel. 36th International Winter Meeting on Nuclear Physics, Jan 1998, Bormio, Italy. pp.170-181. ⟨in2p3-00005088⟩
  • A.D. Nguyen, G. Auger, M. Assenard, E. Galichet, F. Gulminelli, et al.. Space time characterization of nuclear matter in fragmentation processes. International Winter Meeting on Nuclear Physics 36, Jan 1998, Bormio, Italy. pp.307-318. ⟨in2p3-00003706⟩
  • B. Farizon, M. Farizon, M.J. Gaillard, F. Gobet, C. Guillermier, et al.. Fragmentation of hydrogen clusters induced by high energy collisions. SASP Symposium on Atomic and Surface Physics and Related Topics, Jan 1998, Kitzbuehel, Austria. ⟨in2p3-00003806⟩

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