Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J. Genevey, J.A. Pinston, R. Guglielmini, F. Ibrahim, T. Larque, et al.. Identification of \mus isomers in the fission products of ^{241}Pu(n_{th},f). International Workshop on Nuclear Fission and Fission-Product Spectroscopy 2, Apr 1998, Seyssins, France. pp.204-211. ⟨in2p3-00002144⟩
  • F. Brossard, G. Carlot, A. Chevarier, N. Chevarier, D. Crusset, et al.. Use of fission product implantation in nuclear waste management. Workshop on Nuclear Fission and Fission Product Spectroscopy 2, Apr 1998, Seyssins, France. pp.83-91. ⟨in2p3-00014719⟩
  • M. Houry, W. Korten, Y. Le Coz, R. Lucas, Ch. Theisen, et al.. \gamma-ray studies of the fission of ^{238}U induced by ^{12} C spectroscopy and fission dynamics. Workshop on Nuclear Fission and Fission-Product Spectroscopy 2, Apr 1998, Seyssins, France. pp.220-227. ⟨in2p3-00005091⟩
  • M.G. Porquet, I. Deloncle, B.J.P. Gall, F. Hoellinger, N. Schulz, et al.. Odd-even effects in fission induced by heavy ions. Workshop on Nuclear Fission and Fission-Product Spectroscopy 2, Apr 1998, Seyssins, France. pp.212-219. ⟨in2p3-00013097⟩
  • N. Moncoffre. Use of Rutherford Backscattering Spectrometry and nuclear reaction spectroscopy for analytical applications. Ecole SOCRATES, Apr 1998, Oxford, United Kingdom. ⟨in2p3-00003796⟩
  • P. Desgrolard, L. Jenkovszky, F. Paccanoni. Small x all Q^2 proton structure function. Workshop on Deep Inelastic Scattering and QCD 6, Apr 1998, Brussels, Belgium. pp.150-153. ⟨in2p3-00003779⟩
  • O. Drapier. Anomalous J/\psi suppression in Pb-Pb collisions at CERN-SPS. American Physical Society Meeting, Apr 1998, Colombus, United States. ⟨in2p3-00003815⟩
  • M.C. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, J. Astruc, et al.. A possible evidence of Coulomb fission in lead-lead collisions at the CERN SPS. SNEC 98, Nuclear Physics Divisional Conference Structure of Nuclei Under Extreme Conditions. 16, Mar 1998, Padova, Italy. pp.963-969. ⟨in2p3-00002164⟩
  • E. Plagnol, C.O. Bacri, B. Borderie, J.D. Frankland, M.F. Rivet, et al.. Multifragmentation in heavy ion reactions: dynamical effects and thermalization. Workshop Nuclear Matter in Different Phases and Transitions, Mar 1998, Les Houches, France. pp.435-450. ⟨in2p3-00002362⟩
  • R. Barbier, P. Jonsson, S. Katsanevas, N. Vassilopoulos. Search for R-parity violation with a \bar{U}\bar{D}\bar{D} coupling at \sqrt{s} = 183 GeV. HEP'99, Mar 1998, Moriond, France. pp.36. ⟨in2p3-00010796⟩

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