Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks in proton–proton collisions at \sqrt{s}=13\,\text {Te}\text {V}. Eur.Phys.J.C, 2019, 79 (3), pp.280. ⟨10.1140/epjc/s10052-019-6730-7⟩. ⟨hal-01945495⟩
    • Sabine Harribey, Dimitrios Tsimpis. One-loop bosonic string and De Sitter space. Nuclear Physics B, 2019, 948, pp.114768. ⟨10.1016/j.nuclphysb.2019.114768⟩. ⟨hal-01897220⟩
    • B.P. Abbott, R. Abbott, T.D. Abbott, S. Abraham, F. Acernese, et al.. Low-latency gravitational-wave alerts for multimessenger astronomy during the second advanced LIGO and Virgo observing run. Astrophys.J., 2019, 875 (2), pp.161. ⟨10.3847/1538-4357/ab0e8f⟩. ⟨hal-02017735⟩
    • Weiguang Cui, Alexander Knebe, Noam I. Libeskind, Susana Planelles, Xiaohu Yang, et al.. The large-scale environment from cosmological simulations II: The redshift evolution and distributions of baryons. Monthly Notices of the Royal Astronomical Society, 2019, 485 (2), pp.2367-2379. ⟨10.1093/mnras/stz565⟩. ⟨hal-02089632⟩
    • S. Taubenberger, A. Floers, C. Vogl, M. Kromer, J. Spyromilio, et al.. SN 2012dn from early to late times: 09dc-like supernovae reassessed. Monthly Notices of the Royal Astronomical Society, 2019, 488 (4), pp.5473-5488. ⟨10.1093/mnras/stz1977⟩. ⟨hal-02279097⟩
    • C. Aidala, Y. Akiba, M. Alfred, V. Andrieux, N. Apadula, et al.. Nuclear Dependence of the Transverse Single-Spin Asymmetry in the Production of Charged Hadrons at Forward Rapidity in Polarized p+p, p+Al, and p+Au Collisions at \sqrt{s_{_{NN}}}=200 GeV. Physical Review Letters, 2019, 123 (12), pp.122001. ⟨10.1103/PhysRevLett.123.122001⟩. ⟨hal-02371394⟩
    • A. Arbey, J.-F. Coupechoux. Cosmological scalar fields and Big-Bang nucleosynthesis. Journal of Cosmology and Astroparticle Physics, 2019, 11, pp.038. ⟨10.1088/1475-7516/2019/11/038⟩. ⟨hal-02223019⟩
    • W. Ryssens, M. Bender, P.H. Heenen. Iterative approaches to the self-consistent nuclear energy density functional problem: Heavy ball dynamics and potential preconditioning. The European physical journal. A, Hadrons and Nuclei, 2019, 55 (6), pp.93. ⟨10.1140/epja/i2019-12766-6⟩. ⟨hal-01975264⟩
    • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, et al.. Event-shape and multiplicity dependence of freeze-out radii in pp collisions at \sqrt{s} = 7 TeV. Journal of High Energy Physics, 2019, 09, pp.108. ⟨10.1007/JHEP09(2019)108⟩. ⟨hal-01998976⟩
    • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Azimuthal Anisotropy of Heavy-Flavor Decay Electrons in p-Pb Collisions at \sqrt{s_{\rm NN}} = 5.02 TeV. Physical Review Letters, 2019, 122 (7), pp.072301. ⟨10.1103/PhysRevLett.122.072301⟩. ⟨hal-01801863⟩

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