Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Olivier Drapier. Etude des distributions en impulsion transverse des dimuons produits dans les collisions noyau-noyau auprès du SPS du CERN. Physique Nucléaire Théorique [nucl-th]. Université Claude Bernard - Lyon I, 1998. ⟨tel-00001409⟩
  • B. Farizon, M. Farizon, M.J. Gaillard, F. Gobet, J-P. Buchet, et al.. Critical behavior in hydrogen cluster fragmentation induced by high velocity cluster-cluster collision. Workshop on Collisions Involving Atomic Clusters, Jun 1998, Sonderborg, Denmark. ⟨in2p3-00003807⟩
  • J.-M. Mackowski, L. Pinard, L. Dognin, P. Ganau, B. Lagrange, et al.. Different approaches to improve the wavefront of low-loss mirrors used in the VIRGO gravitational wave antenna. Optical Interference Coatings'98, Jun 1998, Tucson, United States. pp.18-20. ⟨in2p3-00003404⟩
  • D. Guinet. Pre-equilibrium emission status report and future. Atelier INDRA 4, May 1998, Caen, France. ⟨in2p3-00003910⟩
  • A. Chevarier. Bases de l'analyse par faisceaux d'ion et analyse par diffusion elastique RBS NBS ERDA. Ecole Thematique ``La Microanalyse Nucleaire par Faisceaux d'Ions - Fondements et Pratique'', May 1998, Saclay, France. ⟨in2p3-00003798⟩
  • A. Astier, S. Perriès, L. Ducroux, M. Meyer, N. Redon, et al.. Decay-out of the yrast highly deformed band in ^{136}Nd : towards and experimental extraction of the neutron pairing gap in the second well. International Spring Seminar on Nuclear Physics : Highlights of Modern Nuclear Structure 6, May 1998, S. Agata Sui Due Golfi, Italy. pp.377-384. ⟨in2p3-00003860⟩
  • S. Pécourt. Matière noire non baryonique détecteurs à scintillation et bolomètres pour la recherche de WIMPs. Cosmology and Extra-Galactic Astrophysics [astro-ph.CO]. Université Claude Bernard - Lyon I, 1998. English. ⟨NNT : ⟩. ⟨in2p3-00000003⟩
  • M.C. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, J. Astruc, et al.. Onset of the anomalous J/\psi suppression in Pb+Pb collisions. Workshop On Quarkonium Production In Relativistic Nuclear Collisions, May 1998, Seattle, United States. pp.35-41. ⟨in2p3-00007740⟩
  • S. Katsanevas. Generators at LEP200. Open LEPC Meeting, May 1998, Geneve, Switzerland. ⟨in2p3-00004568⟩
  • M. Ericson. Chiral symmetry restoration and parity mixing. NATO Advanced Research Workshop on the Structure of Mesons Baryons and Nuclei, May 1998, Cracovie, Poland. pp.2349. ⟨in2p3-00004001⟩

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