Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • G. Canchel, R. Béraud, E. Chabanat, A. Emsallem, N. Redon, et al.. A new 350 ms isomer in ^{125}La and low energy intrinsic states in A=133,131,129,127,125 La isotopes. International Conference on Nuclear Physics Close to the Barrier, Jun 1998, Warsaw, Poland. pp.1239-1244. ⟨in2p3-00003419⟩
  • J. Sauvage, L. Cabaret, J. Crawford, H.T. Duong, J. Genevey, et al.. Nuclear structure of neutron-deficient Au and Pt isotopes from high-resolution laser spectroscopy at ISOLDE. Nuclear Physics Close to the Barrier, Jun 1998, Warsaw, Poland. pp.1393-1407. ⟨in2p3-00013286⟩
  • J. Sauvage, L. Cabaret, J. Crawford, H.T. Duong, J. Genevey, et al.. Nuclear structure of neutron-deficient Au and Pt isotopes from high-resolution laser spectroscopy at ISOLDE. International Conference on Nuclear Physics close to the Barrier, Jun 1998, Warsaw, Poland. pp.1-15. ⟨in2p3-00012926⟩
  • P. Desgrolard, L. Jenkovszky, F. Paccanoni. Can the Pomeron (diffraction) be ``soft'' or ``hard'' ?. International Conference on Strong Interaction at High Energies 14, Jun 1998, Parthenit, Ukraine. pp.78-88. ⟨in2p3-00003784⟩
  • Y. Déclais. Search for neutrino oscillation at reactors. International WEIN Symposium - Physics Beyond the Standard Model, Jun 1998, Santa Fe, United States. pp.784. ⟨in2p3-00007674⟩
  • A. Guichard. Charmonium production in A + A collisions at the SPS. Nuclear Chemistry Gordon Conference, Jun 1998, Boston, United States. ⟨in2p3-00003817⟩
  • R. Béraud. Introduction to classical IGISOL. Workshop on Target and Ion Source Technology, Jun 1998, Caen, France. pp.156-162. ⟨in2p3-00003896⟩
  • R. Béraud. He flow simulations. Workshop on Target and Ion Source Technology, Jun 1998, Caen, France. pp.178-182. ⟨in2p3-00003897⟩
  • D. Jouan, M.C. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, et al.. J/\psi and low masses resonances production in hadron and heavy ions induced collisions around 200 GeV per nucleon. Workshop on Particle Distributions in Hadronic and Nuclear Collisions, Jun 1998, Chicago, United States. ⟨in2p3-00023004⟩
  • Anne Fornier, D. Bernardino, Odile Lam, Jerome Neauport, François Dufour, et al.. High laser damage threshold HfO2/SiO2 mirrors manufactured by sputtering process. Solid State Lasers for Applications (SSLA) to Inertial Confinement Fusion (ICF), Jun 1998, Tucson, United States. pp.250-251, ⟨10.1117/12.354213⟩. ⟨in2p3-00003407⟩

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