Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • C. Bradaschia, P. Ganau, B. Lagrange, J.-M. Mackowski, C. Michel, et al.. VIRGO : a laser interferometer for gravitational waves detection. SIGRAV'98 Conference, Sep 1998, Trami, Italy. ⟨in2p3-00003812⟩
  • S. Katsanevas. Cosmology and LEP. Dark Matter 98, Sep 1998, Sheffield, United Kingdom. ⟨in2p3-00023070⟩
  • B. Farizon, M. Farizon, M.J. Gaillard, F. Gobet, C. Guillermier, et al.. Critical behavior in cluster fragmentation. International Symposium on Small Particules and Inorganics Clusters - ISSPIC 9, Sep 1998, Lausanne, Switzerland. ⟨in2p3-00003947⟩
  • C. Gaillard. Couplage des methodes nucleaires et de la luminescence laser pour l'etude des mecanismes de diffusion des produits de fission dans l'apatite. Journees de Radiochimie 98, Sep 1998, Nantes, France. ⟨in2p3-00003795⟩
  • M. Kibler. On the Wigner-Racah algebra of the group SU_{2} in a non-standard basis. International School on Theoretical Physics 5, Aug 1998, Zajaczkowo, Poland. pp.222-233. ⟨in2p3-00003417⟩
  • M. Lewitowicz, J.M. Daugas, R. Grzywacz, N.L. Achouri, J.C. Angélique, et al.. Study of \mus-isomers in neutron-rich nuclei around Z=28 and N=40 shell closures. International Nuclear Physics Conference INPC 98, Aug 1998, Paris, France. pp.687c-690c, ⟨10.1016/S0375-9474(00)88527-9⟩. ⟨in2p3-00024877⟩
  • S. Leenhardt, F. Azaiez, O. Sorlin, M. Belleguic, C. Bourgeois, et al.. Subshell closure study at N=40 by Coulomb excitation and \beta-decay. International Nuclear Physics Conference INPC 98, Aug 1998, Paris, France. pp.683c-686c. ⟨in2p3-00014781⟩
  • S. Leenhardt, F. Azaiez, O. Sorlin, M. Belleguic, C. Bourgeois, et al.. Subshell closure study at N=40 by Coulomb excitation and \beta-decay. International Nuclear Physics Conference INPC 98, Aug 1998, Paris, France. pp.683c-686c, ⟨10.1016/S0375-9474(00)88526-7⟩. ⟨in2p3-00024876⟩
  • M.C. Abreu, C. Alexa, B. Alessandro, J. Astruc, R. Arnaldi, et al.. Transverse momentum distribution of J/\psi produced in Pb-Pb interactions at 158 GeV/c per nucleon. International Nuclear Physics Conference INPC/98, Aug 1998, Paris, France. pp.640c-643c. ⟨in2p3-00003131⟩
  • S. Perriès, A. Astier, L. Ducroux, M. Meyer, N. Redon, et al.. Decay-out of the yrast superdeformed band in ^{136}Nd towards and experimental extraction of the neutron pairing gap in the second well. International Nuclear Physics Conference - INPC/98, Aug 1998, Paris, France. pp.714c-718c. ⟨in2p3-00005205⟩

Powered by HAL logo