Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- M C. Abreu, M. Atayan, C. Baglin, A. Baldit, A. Baldisseri, et al.. A test pixel vertex spectrometer to complement the NA50 dimuon spectrometer. International Workshop on Vertex Detectors VERTEX'98 7, Sep 1998, Santorini, Greece. pp.161-168. ⟨in2p3-00007715⟩
- J.-P. Walder. Analog signal processing for the CMS electromagnetic calorimeter. Workshop on Electronics for LHC Experiments 4, Sep 1998, Rome, Italy. ⟨in2p3-00007716⟩
- B. Farizon, M. Farizon, M.J. Gaillard, S. Louc, N. Gonçalves, et al.. Collisions of ionized hydrogen clusters with helium atoms: electron capture as a function of the cluster size. Workshop on Fast-Ion-Atom-Collisions - FIAC 7, Sep 1998, Debrecen, Hungary. pp.312-317, ⟨10.1016/S0168-583X(99)00004-X⟩. ⟨in2p3-00002542⟩
- P. Desgrolard, A.I. Lengyel, E.S. Martynov. Soft dipole pomeron model for DIS. International Conference on Hadron Structure - HS98, Sep 1998, Stara Lesna, Slovakia. pp.396-400. ⟨in2p3-00003785⟩
- G. Chanfray. Mésons dans la matière dense et chaude. École thématique. Ecole Joliot Curie "Matière hadronique : de la structure du nucléon au déconfinement des quarks", Maubuisson, (France), du 7-12 septembre 1998 : 17ème session, 1998. ⟨cel-00652933⟩
- G. Chanfray. Mesons dans la matiere hadronique dense et chaude. Ecole Internationale Joliot-Curie, Sep 1998, Maubuisson, France. pp.81. ⟨in2p3-00002491⟩
- M. Masera, M.C. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, et al.. Results from the NA50 experiment. International Symposium on Multiparticle Dynamics 28, Sep 1998, Delphes, Greece. pp.31-42. ⟨in2p3-00009730⟩
- S. Pécourt. Status of the EDELWEISS experiment. International Workshop on New Worlds in Astroparticle Physics 2, Sep 1998, Faro, Portugal. pp.282-286. ⟨in2p3-00003207⟩
- M. Fallavier, Y. Champelovier, M. Ferrari, R. Kirsch, J.-C. Poizat, et al.. Metallic cluster beams from a 2.5 MV Van de Graaff accelerator for cluster-solid interaction studies ; preliminary results with Au
clusters. International Symposium on Small Particles and Inorganics Clusters 9, Sep 1998, Lausanne, Switzerland. pp.529-533. ⟨in2p3-00003432⟩ - C. Bradaschia, P. Ganau, B. Lagrange, J.-M. Mackowski, C. Michel, et al.. VIRGO : a laser interferometer for gravitational waves detection. SIGRAV'98 Conference, Sep 1998, Trami, Italy. ⟨in2p3-00003812⟩
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