The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- P. Abreu, W. Adam, T. Adye, P. Adzic, I. Ajinenko, et al.. Study of the four-jet anomaly observed at LEP centre-of-mass energies of 130 and 136 GeV. Physics Letters B, 1999, 448, pp.311-319. ⟨10.1016/S0370-2693(99)00066-0⟩. ⟨in2p3-00003493⟩
- C. Guillermier. Synthese de molecules organiques dans des conditions quasi interstellaires. Rencontres Jeunes Chercheurs, Dec 1998, Grasse, France. ⟨in2p3-00003948⟩
- E. Simon. Calibrer un bolometre chaleur/ionisation par diffusion neutron pour EDELWEISS. Rencontres Jeunes Chercheurs 1998, Dec 1998, Grasse, France. pp.121-122. ⟨in2p3-00002631⟩
- J. Marteau. De l'effet des interactions nucleaires dans l'anomalie des neutrinos atmospheriques. Rencontres Jeunes Chercheurs 1998, Dec 1998, Grasse, France. pp.49-50. ⟨in2p3-00002633⟩
- G. Grenier. Recherche dans L3 de
degenere en masse avec le
. Rencontres Jeunes Chercheurs 1998, Dec 1998, Grasse, France. pp.89-90. ⟨in2p3-00007649⟩
- F. Brossard. Etude de la migration de l'iode en fonction des differentes phases d'oxydation du zirconium : application au stockage des coques et embouts. Rencontres Jeunes Chercheurs 1998, Dec 1998, Grasse, France. pp.173-174. ⟨in2p3-00002632⟩
- N. Ghodbane. Recherche de leptons de spin nul. Rencontres Jeunes Chercheurs 1998, Dec 1998, Grasse, France. pp.87-88. ⟨in2p3-00002630⟩
- Jacques Marteau. De l'effet des interactions nucléaires dans les réactions de neutrinos sur des cibles d'oxygène et de son rôle dans l'anomalie des neutrinos atmosphèriques. Physique mathématique [math-ph]. Université Claude Bernard - Lyon I, 1998. Français. ⟨NNT : ⟩. ⟨tel-00001398⟩
- M. de Jésus. Expérience EDELWEISS. GDR SUSY groupe LSP, Nov 1998, Saclay, France. ⟨in2p3-00003804⟩
- B. Farizon. Observation d'un comportement critique dans la fragmentation d'agregats d'hydrogene. GDR Agregat, Nov 1998, Carry Le Rouet, France. ⟨in2p3-00003949⟩