Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for the Higgs boson decaying to two muons in proton-proton collisions at \sqrt{s} = 13 TeV. Phys.Rev.Lett., 2019, 122 (2), pp.021801. ⟨10.1103/PhysRevLett.122.021801⟩. ⟨hal-01861919⟩
  • Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. First Observation of an Attractive Interaction between a Proton and a Cascade Baryon. Physical Review Letters, 2019, 123 (11), pp.112002. ⟨10.1103/PhysRevLett.123.112002⟩. ⟨hal-02136313⟩
  • Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. Measurement of the production of charm jets tagged with D^{0} mesons in pp collisions at \sqrt{\mathrm{s}}=7 TeV. Journal of High Energy Physics, 2019, 08, pp.133. ⟨10.1007/JHEP08(2019)133⟩. ⟨hal-02144202⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for a heavy pseudoscalar boson decaying to a Z and a Higgs boson at \sqrt{s} = 13 TeV. Eur.Phys.J.C, 2019, 79 (7), pp.564. ⟨10.1140/epjc/s10052-019-7058-z⟩. ⟨hal-02073505⟩
  • Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. Measurement of {{\mathrm{D}}^0} , {{\mathrm{D}}^+} , {{\mathrm{D}}^{*+}} and {{\mathrm{D}}^+_{\mathrm{s}}} production in pp collisions at {\sqrt{{\textit{s}}}~=~5.02~{\text {TeV}}} with ALICE. European Physical Journal C: Particles and Fields, 2019, 79 (5), pp.388. ⟨10.1140/epjc/s10052-019-6873-6⟩. ⟨hal-02008903⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of nuclear modification factors of \Upsilon(1S), \Upsilon(2S), and \Upsilon(3S) mesons in PbPb collisions at \sqrt{s_{_\mathrm{NN}}} = 5.02 TeV. Phys.Lett.B, 2019, 790, pp.270-293. ⟨10.1016/j.physletb.2019.01.006⟩. ⟨hal-01815186⟩
  • L. Kaya, A. Vogt, P. Reiter, C. Müller-Gatermann, A. Gargano, et al.. Identification of high-spin proton configurations in ^{136}\mathrm{Ba} and ^{137}\mathrm{Ba}. Physical Review C, 2019, 99 (1), pp.014301. ⟨10.1103/PhysRevC.99.014301⟩. ⟨hal-01999090⟩
  • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, et al.. Measuring K^0_{\rm S}K^{\rm{\pm}} interactions using pp collisions at \sqrt{s}=7 TeV. Physics Letters B, 2019, 790, pp.22-34. ⟨10.1016/j.physletb.2018.12.033⟩. ⟨hal-01885533⟩
  • Rebecca Meissner, Linda Feketeová, Anita Ribar, Katharina Fink, Paulo Limão-Vieira, et al.. Electron Ionization of Imidazole and Its Derivative 2-Nitroimidazole. J.Am.Soc.Mass.Spectrom., 2019, 30 (12), pp.2678-2691. ⟨10.1007/s13361-019-02337-w⟩. ⟨hal-02447932⟩
  • Giacomo Cacciapaglia, Thomas Flacke, Myeonghun Park, Mengchao Zhang. Exotic decays of top partners: mind the search gap. Physics Letters B, 2019, 798, pp.135015. ⟨10.1016/j.physletb.2019.135015⟩. ⟨hal-02302833⟩

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