Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Measurement of the average very forward energy as a function of the track multiplicity at central pseudorapidities in proton-proton collisions at \sqrt{s}=13\,\text {TeV}. Eur.Phys.J.C, 2019, 79 (11), pp.893. ⟨10.1140/epjc/s10052-019-7402-3⟩. ⟨hal-02290766⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Combination of searches for Higgs boson pair production in proton-proton collisions at \sqrt{s} = 13 TeV. Phys.Rev.Lett., 2019, 122 (12), pp.121803. ⟨10.1103/PhysRevLett.122.121803⟩. ⟨hal-01952809⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for pair production of vectorlike quarks in the fully hadronic final state. Phys.Rev.D, 2019, 100 (7), pp.072001. ⟨10.1103/PhysRevD.100.072001⟩. ⟨hal-02188852⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for nonresonant Higgs boson pair production in the \mathrm{b\overline{b}b\overline{b}} final state at \sqrt{s} = 13 TeV. JHEP, 2019, 04, pp.112. ⟨10.1007/JHEP04(2019)112⟩. ⟨hal-01921975⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for low-mass resonances decaying into bottom quark-antiquark pairs in proton-proton collisions at \sqrt{s} = 13 TeV. Phys.Rev.D, 2019, 99 (1), pp.012005. ⟨10.1103/PhysRevD.99.012005⟩. ⟨hal-01921792⟩
    • Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for the Higgs boson decaying to two muons in proton-proton collisions at \sqrt{s} = 13 TeV. Phys.Rev.Lett., 2019, 122 (2), pp.021801. ⟨10.1103/PhysRevLett.122.021801⟩. ⟨hal-01861919⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of inclusive very forward jet cross sections in proton-lead collisions at \sqrt{s_{\mathrm{NN}}} = 5.02 TeV. JHEP, 2019, 05, pp.043. ⟨10.1007/JHEP05(2019)043⟩. ⟨hal-01959717⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for the pair production of light top squarks in the e^{\pm}\mu^{\mp} final state in proton-proton collisions at \sqrt{s} = 13 TeV. JHEP, 2019, 03, pp.101. ⟨10.1007/JHEP03(2019)101⟩. ⟨hal-01990826⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of nuclear modification factors of \Upsilon(1S), \Upsilon(2S), and \Upsilon(3S) mesons in PbPb collisions at \sqrt{s_{_\mathrm{NN}}} = 5.02 TeV. Phys.Lett.B, 2019, 790, pp.270-293. ⟨10.1016/j.physletb.2019.01.006⟩. ⟨hal-01815186⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for a heavy pseudoscalar boson decaying to a Z and a Higgs boson at \sqrt{s} = 13 TeV. Eur.Phys.J.C, 2019, 79 (7), pp.564. ⟨10.1140/epjc/s10052-019-7058-z⟩. ⟨hal-02073505⟩

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