Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • P. Abreu, W. Adam, T. Adye, I. Ajinenko, G D. Alekseev, et al.. Measurement of the Quark and Gluon Fragmentation Functions in Z^0 Hadronic Decays. European Physical Journal C: Particles and Fields, 1999, 6, pp.19-33. ⟨10.1007/s100529801013⟩. ⟨in2p3-00003487⟩
  • P. Abreu, T. Adye, P. Adzic, I. Ajinenko, G D. Alekseev, et al.. Search for pair-produced neutralinos in events with photons and missing energy from e^+ e^- collisions at \sqrt{s} = 130-183 GeV. European Physical Journal C: Particles and Fields, 1999, 6, pp.371-384. ⟨10.1007/s100529801044⟩. ⟨in2p3-00001125⟩
  • P. Abreu, W. Adam, T. Adye, P. Adzic, T. Aldeweireld, et al.. Search for lightest neutralino and stau pair production in light gravitino scenarios with stau NLSP. European Physical Journal C: Particles and Fields, 1999, 7, pp.595-607. ⟨10.1007/PL00021671⟩. ⟨in2p3-00001123⟩
  • A. Astier. Multidetecteurs \gamma et decouverte de bandes dipolaries dans la region de noyaux superdeformes de mass A \sim 190. Nuclear Experiment [nucl-ex]. Université Claude Bernard - Lyon I, 1999. ⟨in2p3-00004220⟩
  • M. Bedjidian, O.L. Kodolova, I.P. Lokhtin, L.I. Sarycheva, A.M. Snigirev, et al.. Jet physics in CMS heavy ion programme. 1999. ⟨in2p3-00003822⟩
  • J. Jagielski, N. Moncoffre, P. Delichère, G. Marest. On the possibility of b-C3N4 carbon nitride synthesis via C and N implantation into copper. Journal of Materials Science, 1999, 34, pp.2949. ⟨in2p3-00003036⟩
  • F. Delduc, F. Gieres, S. Gourmelen, S. Theisen. Non-standard matrix formats of Lie superalgebras. International Journal of Modern Physics A, 1999, 14, pp.4043-4060. ⟨10.1142/S0217751X99001895⟩. ⟨in2p3-00003482⟩
  • G. Auger, Ch.O. Bacri, B. Borderie, R. Bougault, R. Brou, et al.. INDRA et les noyaux chauds: bilan et perspectives. 1999, pp.1-16. ⟨in2p3-00002559⟩
  • M. Acciarri, P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, et al.. Measurement of the cross-section for the process \gamma^{\star}\gamma^{\star} \to hadrons at LEP. Physics Letters B, 1999, 453, pp.333-342. ⟨10.1016/S0370-2693(99)00278-6⟩. ⟨in2p3-00003489⟩
  • M. Acciarri, O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, et al.. Searches for Scalar Top and Scalar Bottom Quarks in e^+ e^- Interactions at 161 GeV \leq \sqrt{s} \leq 183 Gev. Physics Letters B, 1999, 445, pp.428-438. ⟨10.1016/S0370-2693(98)01505-6⟩. ⟨in2p3-00000251⟩

Powered by HAL logo