Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M. Acciarri, O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, et al.. Searches for Scalar Top and Scalar Bottom Quarks in e^+ e^- Interactions at 161 GeV \leq \sqrt{s} \leq 183 Gev. Physics Letters B, 1999, 445, pp.428-438. ⟨10.1016/S0370-2693(98)01505-6⟩. ⟨in2p3-00000251⟩
  • M. Acciarri, P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, et al.. Measurement of Mass and Width of the W Boson at LEP. Physics Letters B, 1999, 454, pp.386-398. ⟨10.1016/S0370-2693(99)00348-2⟩. ⟨in2p3-00003526⟩
  • M. Acciarri, P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, et al.. Measurement of Triple-Gauge-Boson Couplings of the W Boson at LEP. Physics Letters B, 1999, 467, pp.171-184. ⟨10.1016/S0370-2693(99)01195-8⟩. ⟨in2p3-00003719⟩
  • M. Acciarri, P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, et al.. Search for R-parity Violating Chargino and Neutralino Decays in e^+ e^- Collisions up to \sqrt{s}= 183 GeV. Physics Letters B, 1999, 459, pp.354-366. ⟨10.1016/S0370-2693(99)00680-2⟩. ⟨in2p3-00003565⟩
  • G. Chanfray, J. Delorme, M. Ericson, M. Rosa-Clot. Axial and Vector Correlator Mixing in Hot and Dense Hadronic Matter. Physics Letters B, 1999, 455, pp.39. ⟨in2p3-00003411⟩
  • M. Kodama, N. Ushida, M. Guler, E. Pesen, M. Serin-Zeyrek, et al.. A long baseline \nu_\tau appearance experiment in the CNGS beam from CERN to Gran Sasso - (Progress Report). 1999, pp.119. ⟨in2p3-00007667⟩
  • G. Tabacaru, B. Borderie, A. Ouatizerga, M. Pârlog, M.F. Rivet, et al.. Pulse-height defect in the passivated ion-implanted Si detectors of the INDRA array. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1999, 428, pp.379-390. ⟨in2p3-00009643⟩
  • P. Abreu, W. Adam, T. Adye, P. Adzic, Z. Albrecht, et al.. Search for charged Higgs bosons at LEP 2. Physics Letters B, 1999, 460, pp.484-497. ⟨10.1016/S0370-2693(99)00771-6⟩. ⟨in2p3-00002653⟩
  • M. Acciarri, P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, et al.. Search for the standard model Higgs boson in e^+ e^- interactions at \sqrt{s} = 189 GeV. Physics Letters B, 1999, 461, pp.376-386. ⟨10.1016/S0370-2693(99)00853-9⟩. ⟨in2p3-00003674⟩
  • M. Acciarri, P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, et al.. Measurement of the e^+ e^- \to Z \to b\overline{b} forward-backward asymmetry and the B^{0}\overline{B}^0 mixing parameter using prompt leptons. Physics Letters B, 1999, 448, pp.152-162. ⟨10.1016/S0370-2693(98)01601-3⟩. ⟨in2p3-00003513⟩

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