Health

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

SAADE Gaëlle

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8785 documents

Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, et al.. Measuring K $^0_{\rm S}$ K $^{\rm{\pm}}$ interactions using pp collisions at $\sqrt{s}=7$ TeV. Physics Letters B, 2019, 790, pp.22-34. ⟨10.1016/j.physletb.2018.12.033⟩. ⟨hal-01885533⟩
Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. Measurement of ${{\mathrm{D}}^0}$ , ${{\mathrm{D}}^+}$ , ${{\mathrm{D}}^{*+}}$ and ${{\mathrm{D}}^+_{\mathrm{s}}}$ production in pp collisions at ${\sqrt{{\textit{s}}}~=~5.02~{\text {TeV}}}$ with ALICE. European Physical Journal C: Particles and Fields, 2019, 79 (5), pp.388. ⟨10.1140/epjc/s10052-019-6873-6⟩. ⟨hal-02008903⟩
Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Measurement of the average very forward energy as a function of the track multiplicity at central pseudorapidities in proton-proton collisions at $\sqrt{s}=13\,\text {TeV}$ . European Physical Journal C: Particles and Fields, 2019, 79 (11), pp.893. ⟨10.1140/epjc/s10052-019-7402-3⟩. ⟨hal-02290766⟩
Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of nuclear modification factors of $\Upsilon$ (1S), $\Upsilon$ (2S), and $\Upsilon$ (3S) mesons in PbPb collisions at $\sqrt{s_{_\mathrm{NN}}} =$ 5.02 TeV. Phys.Lett.B, 2019, 790, pp.270-293. ⟨10.1016/j.physletb.2019.01.006⟩. ⟨hal-01815186⟩
Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. First Observation of an Attractive Interaction between a Proton and a Cascade Baryon. Physical Review Letters, 2019, 123 (11), pp.112002. ⟨10.1103/PhysRevLett.123.112002⟩. ⟨hal-02136313⟩
Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. Measurement of the production of charm jets tagged with D $^{0}$ mesons in pp collisions at $\sqrt{\mathrm{s}}=7$ TeV. Journal of High Energy Physics, 2019, 08, pp.133. ⟨10.1007/JHEP08(2019)133⟩. ⟨hal-02144202⟩
Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. Measurement of charged jet cross section in $pp$ collisions at ${\sqrt{s}=5.02}$ TeV. Physical Review D, 2019, 100 (9), pp.092004. ⟨10.1103/PhysRevD.100.092004⟩. ⟨hal-02144198⟩
L. Kaya, A. Vogt, P. Reiter, C. Müller-Gatermann, A. Gargano, et al.. Identification of high-spin proton configurations in $^{136}\mathrm{Ba}$ and $^{137}\mathrm{Ba}$ . Physical Review C, 2019, 99 (1), pp.014301. ⟨10.1103/PhysRevC.99.014301⟩. ⟨hal-01999090⟩
Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Suppression of $\Lambda(1520)$ resonance production in central Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV. Physical Review C, 2019, 99, pp.024905. ⟨10.1103/PhysRevC.99.024905⟩. ⟨hal-01801870⟩
Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of inclusive very forward jet cross sections in proton-lead collisions at $\sqrt{s_{\mathrm{NN}}}$ = 5.02 TeV. Journal of High Energy Physics, 2019, 05, pp.043. ⟨10.1007/JHEP05(2019)043⟩. ⟨hal-01959717⟩

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