Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • F. Bocage, J. Colin, M. Louvel, G. Auger, Ch.O. Bacri, et al.. Dynamical effects in nuclear collisions in the Fermi energy range : the case of heavy systems. Winter Meeting on Nuclear Physics 37, Jan 1999, Bormio, Italy. pp.241-256. ⟨in2p3-00002509⟩
  • O.F. Smidts, A. Dubus, Z. Vidovic, A. Billebaud, M. Fallavier, et al.. Theoretical and experimental study of the correlation between forward and backward electron emissions induced by H^0 or H^+ projectiles incident on carbon foils. International Workshop on Inelastic Ion Surface Collisions 12, Jan 1999, South Padre Island, United States. pp.239-244. ⟨in2p3-00003651⟩
  • P. Martin. Etude des mécanismes de diffusion thermique et de diffusion sous irradiation alpha des terres rares dans les apatites. Nuclear Experiment [nucl-ex]. Université Claude Bernard - Lyon I, 1999. English. ⟨NNT : ⟩. ⟨in2p3-00007622⟩
  • A. Krikeb, A. Martin, J.-M. Richard, T T. Wu. On the Stability Domain of Systems of Three Arbitrary Charges. 1999. ⟨in2p3-00000336⟩
  • M. Houry, C. Theisen, R. Lucas, F. Becker, W. Korten, et al.. \gamma-ray studies of induced fission ^{12}C+^{238}U. International Conference on the Nucleus: New Physics for the New Millennium, Jan 1999, Faure, South Africa. pp.293-295. ⟨in2p3-00013516⟩
  • M-F. Rivet, B. Borderie, J.D. Frankland, Ch.O. Bacri, M. Pârlog, et al.. Multifragmentation of heavy systems around the Fermi energy : compression radial expansion and volume instabilities. Workshop on Nuclear Gross Properties of Nuclei and Nuclear Excitations, Hirschegg 27, Jan 1999, Hirschegg, Austria. pp.293-305. ⟨in2p3-00002507⟩
  • R. Bougault, J.P. Wieleczko, M. d'Agostino, W A. Friedman, N. Le Neindre, et al.. Time dependence of the multifragmentation process in 50 A MeV Xe + Sn reactions. International Workshop on Gross Properties of Nuclei and Nuclear Excitations, Hirschegg, Jan 1999, Hirschegg, Austria. pp.24-35. ⟨in2p3-00003593⟩
  • S. Perriès. Propriétés de la matière nucleaire superdéformée dans les régions de masse \simeq 190 et A \simeq 130. Nuclear Experiment [nucl-ex]. Université Claude Bernard - Lyon I, 1999. English. ⟨NNT : ⟩. ⟨in2p3-00003589⟩
  • M. Houry, R. Lucas, M.G. Porquet, C. Theisen, M. Girod, et al.. Structure of neutron rich palladium isotopes produced in heavy ion induced fission. The European physical journal. A, Hadrons and Nuclei, 1999, 6, pp.43-48. ⟨in2p3-00005196⟩
  • G. Gerbier, J. Mallet, L. Mosca, C. Tao, B. Chambon, et al.. Pulse shape discrimination and dark matter search with NaI(Tl) scintillator. Astroparticle Physics, 1999, 11, pp.287-302. ⟨10.1016/S0927-6505(99)00004-3⟩. ⟨in2p3-00003428⟩

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