Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • G.-S. Muanza. Search for the S.M. Higgs boson in e^+e^- interactions at \sqrt{s} = 189 GeV. APS Centennial Conference, Mar 1999, Atlanta, United States. ⟨in2p3-00014807⟩
  • A. Jokinen, J-C. Wang, J. Aysto, G. Canchel, P. Dendooven, et al.. Evolution of structures in neutron-rich Pd isotopes probed by beta decay. Workshop on the Beta Decay from Weak Interaction to Nuclear Structure, Mar 1999, Strasbourg, France. pp.115-117. ⟨in2p3-00003208⟩
  • O. Sorlin, C. Donzaud, L. Axelsson, M. Belleguic, R. Béraud, et al.. Beta decay half-lives of neutron rich Ti-Co isotopes around N=40. Workshop on the beta decay from weak interaction to nuclear structure, Mar 1999, Strasbourg, France. pp.65-70. ⟨in2p3-00003196⟩
  • G. Canchel, R. Béraud, E. Chabanat, A. Emsallem, P. Dendooven, et al.. A new isomer in ^{125}La. Workshop on the Beta Decay from Weak Interaction to Nuclear Structure, Mar 1999, Strasbourg, France. pp.148-153. ⟨in2p3-00003209⟩
  • M. Ericson. Chiral symmetry and its manifestations. ECT Workshop on Electromagnetic probes of in-medium effects in strongly interacting systems, Mar 1999, Trento, Italy. ⟨in2p3-00003780⟩
  • G. Chanfray. Axial-vector mixing and chiral symmetry restoration in dilepton production. ECT Workshop on Electromagnetic probes of in-medium effects in strongly interacting systems, Mar 1999, Trento, Italy. ⟨in2p3-00003781⟩
  • J. Marteau, J. Delorme, M. Ericson. Neutrino-oxygen interactions role of nuclear physics in the atmospheric neutrino anomaly. Rencontres de Moriond session on Electroweak Interactions and Unified Theories, Mar 1999, Les Houches, France. pp.9. ⟨in2p3-00002735⟩
  • N. Buforn, A. Astier, M. Meyer, S. Perriès, N. Redon, et al.. Structure a haut spin des isotopes ^{113-116}Cd produits par reaction de fission induite par ions lourds. Rencontre Franco-Marocaine de Physique Nucleaire, Mar 1999, El Jadida, Morocco. pp.107-111. ⟨in2p3-00005173⟩
  • I. Laktineh. Scalar leptons searches at LEP. Higgs and Supersymmetrie Search and Discovery, Mar 1999, Gainesville, United States. ⟨in2p3-00003264⟩
  • I. Laktineh. SUSYGEN Supersymmetric particles generators. Higgs and Supersymmetrie Search and Discovery, Mar 1999, Gainesville, United States. ⟨in2p3-00003265⟩

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