Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Anne-Marie Maskay-Wallez. Nouvelle méthode de selection et caractérisation des événements monosource dans les collisions Ni + Ni à 32 A.MeV. Physique Nucléaire Théorique [nucl-th]. Université Claude Bernard - Lyon I, 1999. Français. ⟨NNT : ⟩. ⟨tel-00007280⟩
  • N. Buforn, A. Astier, J. Meyer, M. Meyer, S. Perriès, et al.. High-spin structure of the ^{113-116}Cd isotopes produced by heavy-ion induced fission reaction. International Conference on Achievements and Perspectives in Nuclear Structure, Jul 1999, Aghia Palaghia, Greece. pp.45-48. ⟨in2p3-00009782⟩
  • J. Marteau, J. Delorme, M. Ericson. Effets nucleaires dans les interactions de neutrinos atmospheriques avec des noyaux. NUFACT'99, Jul 1999, Lyon, France. pp.7. ⟨in2p3-00003813⟩
  • J. Gascon. Matiere noire : detections directe et indirecte de WIMPs. Colloque Cosmologie Observationnelle, Congres de la SFP, Jul 1999, Clermont-Ferrand, France. ⟨in2p3-00003802⟩
  • J. Marteau, J. Delorme, M. Ericson. Nuclear effects in neutrino-nucleus interactions. ICFA/ECFA Workshop on Neutrino Factories based on Muon Storage Rings - NUFACT'99, Jul 1999, Lyon, France. pp.8. ⟨in2p3-00005629⟩
  • J. Genevey, J.A. Pinston, C. Foin, R. Béraud, E. Chabanat, et al.. Microsecond isomers in fission fragments in the vicinity of the doubly magic ^{132}Sn. International Conference on Fission and Neutron Rich Nuclei 2, Jun 1999, St Andrews, United Kingdom. pp.162-165. ⟨in2p3-00005275⟩
  • R. Lucas, M. Houry, Ch. Theisen, F. Becker, W. Korten, et al.. Study of fission fragments from ^{12}C + ^{238}U reactions : prompt and delayed spectroscopy. International Conference on Fission and Neutron Rich Nuclei 2, Jun 1999, St Andrews, United Kingdom. pp.79-88. ⟨in2p3-00006464⟩
  • N. Buforn, A. Astier, J. Meyer, M. Meyer, S. Perriès, et al.. High spin structure of the ^{113-116}Cd isotopes produced by heavy-ion induced fission reaction. International Conference on Fission and Neutron-Rich Nuclei 2, Jun 1999, St Andrews, United Kingdom. pp.144-148. ⟨in2p3-00005265⟩
  • F. Brossard, N. Chevarier, N. Moncoffre, D. Crusset. Etude de la migration de l'iode dans la zircone. Journee ANDRA des Doctorants, Jun 1999, Paris, France. pp.114-121. ⟨in2p3-00003788⟩
  • M. Goyot. A versatile fast low noise preamplifier in UHF bipolar technology. International Conference on New Developments in Photodetection 2, Jun 1999, Beaune, France. pp.374-377. ⟨in2p3-00005346⟩

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