Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • K. Poulard, A. Chevarier, J.-C. Duclot, N. Moncoffre, D. Crusset. Use of RBS to validate Europium surface implantation as a marker for the corrosion study of zirconia. Ion Beam Analysis Conference, Jul 1999, Dresden, Germany. pp.668-672. ⟨in2p3-00005172⟩
  • F. Brossard, A. Chevarier, N. Chevarier, N. Moncoffre, H. Jaffrezic, et al.. Effect of ion irradiation on the retention of iodine in zirconia. International Conference on Radiation Effects in Insulators 10, Jul 1999, Jena, Germany. ⟨in2p3-00012115⟩
  • A. de Falco, M.C. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, et al.. Study of J/\Psi suppression in Pb-Pb collisions at the CERN SPS. International Europhysics Conference on High Energy Physics HEP-EPS 99, Jul 1999, Tampere, Finland. pp.959-961. ⟨in2p3-00007902⟩
  • P. Allport, A. Galloni, G.J. Hughes, M. Berggren, R. Pain, et al.. Searches for Sleptons using the DELPHI detector at LEP. HEP'99 Conference, Jul 1999, Tampere, Finland. pp.24. ⟨in2p3-00003683⟩
  • G. Grenier. Search for radiative pair production of charginos with masses close to the LSP mass. International Europhysics Conference High Energy Physics'99, Jul 1999, Tampere, Finland. ⟨in2p3-00003210⟩
  • P. Lebrun, L. Lugnier, G.-S. Muanza. Missing mass spectra in leptonic and hadronic events form e^+e^- collisions at \sqrt{s} = 189 GeV and limits on invisible Higgs decays. International Europhysics Conference High Energy Physics'99, Jul 1999, Tampere, Finland. ⟨in2p3-00014805⟩
  • P. Antilogus, I. Bozovic, M. Calvi, E. Cortina, Ch. de La Vaissiere, et al.. Measurement of the semileptonic b branching ratios in Z decays. HEP'99 Conference, Jul 1999, Tampere, Finland. pp.36. ⟨in2p3-00003685⟩
  • R. Barbier, P. Jonsson, S. Katsanevas. Search for R-parity violation with a \bar{U}\bar{D}\bar{D} coupling at \sqrt{s} = 189 GeV. HEP'99 Conference, Jul 1999, Tampere, Finland. pp.19. ⟨in2p3-00003686⟩
  • L. Chaussard, A. Miagkov, G. Smadja. Measurement of the beauty baryon form factor. HEP'99 Conference, Jul 1999, Tampere, Finland. pp.16. ⟨in2p3-00003687⟩
  • P. Checchia, A. de Min, E. Falk, P. Ferrari, V. Hedberg, et al.. Photon events with missing energy at LEP2. HEP'99 Conference, Jul 1999, Tampere, Finland. pp.18. ⟨in2p3-00003724⟩

Powered by HAL logo