Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • G. Chardin, Angélique Benoit, L. Bergé, A. Broniatowski, B. Chambon, et al.. Status of the EDELWEISS experiment. International workshop on low temperature detectors 8 LTD-8, Aug 1999, Dalfsen, Netherlands. pp.319-322. ⟨in2p3-00005351⟩
  • D. Idzik, M.C. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, et al.. Summary of J/\psi suppression data and preliminary results on multiplciity distributions in Pb-Pb collisions from the NA50 experiment. International Symposium on Multiparticle Dynamics 29, Aug 1999, Providence,Rhod Island, United States. ⟨in2p3-00012123⟩
  • M. Fallavier, R. Kirsch, J.-C. Poizat, J. Remillieux, J.-P. Thomas. Backward electron emission from carbon and gold foils under impact of MeV Au^+_n clusters. International Conference on Atomic Collisions in Solids 18, Aug 1999, Odense, Denmark. pp.920-926. ⟨in2p3-00014802⟩
  • B. Canut, M. Fallavier, O. Marty, S.M.M. Ramos. Damage creation in silicon single crystals irradiated with 200 keV/atom Au+_n clusters. International Conference on Atomic Collisions in Solids 18, Aug 1999, Odense, Denmark. pp.396-400. ⟨in2p3-00009668⟩
  • M. de Jésus. Status of EDELWEISS. Dark Matter Tools, Aug 1999, Geneve, Switzerland. ⟨in2p3-00003803⟩
  • M. Kibler. Fractional supersymmetric oscillator and its supercoherent states. International Wigner Symposium 6, Aug 1999, Istanbul, Turkey. ⟨in2p3-00003775⟩
  • K. Turzo. A study of the reaction mechanisms of colliding nuclei for a wide range of energy and mass. Mazurian Lakes School of Physics 26, Aug 1999, Piaski, Poland. ⟨in2p3-00003909⟩
  • B. Farizon, M. Farizon, H. Razafinjanahary, H. Chermette. Structure and energetics of the H^+_{15} hydrogen clusters. Physical Review B: Condensed Matter and Materials Physics (1998-2015), 1999, 60 (6), pp.3821-3828. ⟨10.1103/PhysRevB.60.3821⟩. ⟨in2p3-00002540⟩
  • F. Gieres. Conformal covariance in 2d conformal and integrable models, in W-algebras and in their supersymmetric extensions. Workshop on Supersymmetries and Quantum Symmetries - SQS'99, Jul 1999, Dubna, Russia. pp.274-284. ⟨in2p3-00007757⟩
  • C. Gaillard, N. Chevarier, N. Millard-Pinard, P. Delichère, Ph. Sainsot. Thermal diffusion of molybdenum in apatite. International Conference on Ion Beam Analysis 14 European Conference on Accelerators in Applied Research and Technology 6, Jul 1999, Dresden, Germany. pp.646-650. ⟨in2p3-00012100⟩

Powered by HAL logo