Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M. Chemarin, H. El Mamouni, J. Fay, G. Grenier, I. Laktineh, et al.. Search for charginos with small mass difference to the lightest supersymmetric particle in e^+e^- collisions at \sqrt{s} = 189-202 GeV. International Conference on High Energy Physics 30 ICHEP 2000, 2000, Osaka, Japan. ⟨in2p3-00010727⟩
  • A.-M. Maskay, P. Lautesse, P. Desesquelles, E. Gerlic, J.L. Laville, et al.. Ni+Ni collisions at 32 MeV/u: experimental insight with the INDRA multidetector. Bologna 2000 Structure of the Nucleus at the Dawn of the Century, 2000, Bologna, Italy. pp.363-366. ⟨in2p3-00011166⟩
  • M. Chemarin, H. El Mamouni, J. Fay, G. Grenier, I. Laktineh, et al.. Search for charginos and neutralinos in e^+e^- collisions at \sqrt{s} = 192-202 GeV. International Conference on High Energy Physics 30 ICHEP 2000, 2000, Osaka, Japan. ⟨in2p3-00010726⟩
  • P. Desgrolard, M. Giffon, E. Martynov, E. Predazzi. Eikonalization and unitarity constraints. European Physical Journal C: Particles and Fields, 2000, 14, pp.683-694. ⟨in2p3-00005264⟩
  • E. Galichet, F. Gulminelli, D. Guinet. Use of charge density for probing the parameters of a microscopic transport model (BNV). International Conference on Collisions Nucleus Nucleus 7, 2000, Strasbourg, France. ⟨in2p3-00008280⟩
  • J. Jeanjean, J. Collot, P. Depasse, F. Didierjean, G. Prévôt, et al.. Journee imagerie. Journee Imagerie, 2000, Paris, France. pp.PM. ⟨in2p3-00022973⟩
  • P. Abreu, W. Adam, T. Adye, P. Adzic, I. Ajinenko, et al.. Rapidity-rank structure of p\overline{p} pairs in hadronic Z^0 decays. Physics Letters B, 2000, 490, pp.61-70. ⟨10.1016/S0370-2693(00)00868-6⟩. ⟨in2p3-00005706⟩
  • P. Abreu, W. Adam, T. Adye, P. Adzic, Z. Albrecht, et al.. Search for Heavy Stable and Long-Lived Particles in e^+ e^- Collisions at \sqrt{s}=189 GeV. Physics Letters B, 2000, 478, pp.65-72. ⟨10.1016/S0370-2693(00)00265-3⟩. ⟨in2p3-00004109⟩
  • P. Desesquelles, A.-M. Maskay, P. Lautesse, A. Demeyer, E. Gerlic, et al.. New method for the discrimination of single-source events in heavy-ion collisions. Physical Review C, 2000, 62, pp.024614-1-024614-8. ⟨10.1103/PhysRevC.62.024614⟩. ⟨in2p3-00009760⟩
  • P. Verdier. Recherche des Squarks dans le detecteur DELPHI. Journees jeunes chercheurs 1999, Dec 1999, Balaruc-Les-Bains, pp.7-8. ⟨in2p3-00009087⟩

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