Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- P. Abreu, W. Adam, T. Adye, P. Adzic, I. Ajinenko, et al.. Photon Events with Missing Energy at
= 183 to 189 GeV. European Physical Journal C: Particles and Fields, 2000, 17, pp.53-65. ⟨10.1007/s100520000434⟩. ⟨in2p3-00005292⟩ - P. Abreu, W. Adam, T. Adye, P. Adzic, I. Ajinenko, et al.. Inclusive
and 
production in hadronic Z decays. Physics Letters B, 2000, 475, pp.429-447. ⟨10.1016/S0370-2693(00)00081-2⟩. ⟨in2p3-00004112⟩ - P. Abreu, W. Adam, T. Adye, P. Adzic, I. Azhinenko, et al.. Search for supersymmetry with R-parity violating
couplings at = 183 GeV. European Physical Journal C: Particles and Fields, 2000, 13, pp.591-608. ⟨10.1007/s100520050720⟩. ⟨in2p3-00003638⟩ - Marie Germain, D. Gourio, Philippe Eudes, J.L. Laville, T. Reposeur, et al.. Evidence for dynamical proton emission in peripheral Xe + Sn collisions at 50 MeV/u. Physics Letters B, 2000, 488, pp.211-217. ⟨10.1016/S0370-2693(00)00861-3⟩. ⟨in2p3-00005978⟩
- T. Lefort, D. Dore, D. Cussol, Y.G. Ma, J. Peter, et al.. Study of intermediate velocity products in the Ar+Ni collisions between 52 and 95 A.MeV. Nuclear Physics A, 2000, 662, pp.397-422. ⟨10.1016/S0375-9474(99)00402-9⟩. ⟨in2p3-00003952⟩
- M. Acciarri, P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, et al.. Determination of
interference in 
annihilation at LEP. Physics Letters B, 2000, 489, pp.93-101. ⟨10.1016/S0370-2693(00)00889-3⟩. ⟨in2p3-00005594⟩ - M. Acciarri, P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, et al.. Measurement of the Lifetime of the
Lepton. Physics Letters B, 2000, 479, pp.67-78. ⟨10.1016/S0370-2693(00)00347-6⟩. ⟨in2p3-00005340⟩ - Alain Benoit, L. Bergé, A. Broniatowski, B. Chambon, M. Chapellier, et al.. Event categories in the EDELWEISS WIMP search experiment. Physics Letters B, 2000, 479, pp.8-14. ⟨10.1016/S0370-2693(00)00264-1⟩. ⟨hal-00096581⟩
- M.C. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, et al.. Evidence for deconfinement of quarks and gluons from the
suppression pattern measured in Pb-Pb collisions at the CERN-SPS. Physics Letters B, 2000, 477, pp.28-36. ⟨10.1016/S0370-2693(00)00237-9⟩. ⟨in2p3-00007753⟩ - M. Acciarri, P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, et al.. Search for manifestations of new physics in fermion-pair production at LEP. Physics Letters B, 2000, 489, pp.81-92. ⟨10.1016/S0370-2693(00)00887-X⟩. ⟨in2p3-00005411⟩
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