Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M. Acciarri, P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, et al.. Measurement of R_{b} and BR(b \to \ell \nu X) at LEP Using Double-Tag Methods. European Physical Journal C: Particles and Fields, 2000, 13, pp.47-61. ⟨10.1007/s100520100612⟩. ⟨in2p3-00003711⟩
  • Peter Bettess, Omar Laghrouche, Joseph Shirron, Bernard Peseux. Semi-Analytical Integration Rules for Special Wave Finite Elements. 7th International Congress on Sound and Vibration, 2000, Garmisch-Partenkirchen, Germany. ⟨hal-01008880⟩
  • F. Brossard, Noëlle Chevarier, Nathalie Moncoffre, Philippe Sainsot, Didier Crusset, et al.. Thermal iodine release of surface implanted iodine in zirconia and its affect on hull disposal. Journal of Nuclear Materials, 2000, 279 (2-3), pp.153-161. ⟨10.1016/S0022-3115(00)00020-9⟩. ⟨in2p3-00005280⟩
  • N. Buforn, A. Astier, J. Meyer, M. Meyer, S. Perriès, et al.. Evidence for deformation in ^{113-116}Cd isotopes. The European physical journal. A, Hadrons and Nuclei, 2000, 7, pp.347-353. ⟨10.1007/PL00013614⟩. ⟨in2p3-00015095⟩
  • P. Abreu, W. Adam, T. Adye, P. Adzic, Z. Albrecht, et al.. Search for SUSY with R-parity violating LL\overline{E} couplings at \sqrt{s}=189 GeV. Physics Letters B, 2000, 487, pp.36-52. ⟨10.1016/S0370-2693(00)00776-0⟩. ⟨in2p3-00005632⟩
  • M C. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, J. Astruc, et al.. Low mass dimuon production in proton and ion induced interactions at SPS. European Physical Journal C: Particles and Fields, 2000, 13, pp.69-78. ⟨10.1007/s100520000288⟩. ⟨in2p3-00003710⟩
  • P. Abreu, W. Adam, T. Adye, P. Adzic, Z. Albrecht, et al.. Two-dimensional analysis of the Bose-Einstein correlations in e^+ e^- annihilation at the Z^0 peak. Physics Letters B, 2000, 471, pp.460-470. ⟨10.1016/S0370-2693(99)01391-X⟩. ⟨in2p3-00003905⟩
  • P. Abreu, W. Adam, T. Adye, P. Adzic, Z. Albrecht, et al.. Consistent measurements of \alpha_s from precise oriented event shape distributions. European Physical Journal C: Particles and Fields, 2000, 14, pp.557-584. ⟨10.1007/s100520000354⟩. ⟨in2p3-00005207⟩
  • P. Abreu, W. Adam, T. Adye, P. Adzic, Z. Albrecht, et al.. Measurement of the B^0_s Lifetime and Study of B^0_s - \overline{B^0_s} Oscillations using D_{s}l Events. European Physical Journal C: Particles and Fields, 2000, 16, pp.555-578. ⟨10.1007/s100520000415⟩. ⟨in2p3-00005631⟩
  • P. Abreu, W. Adam, T. Adye, P. Adzic, I. Azhinenko, et al.. Determination of P(c \to D^{*+}) and BR(c \to l^{+}) at LEP1. European Physical Journal C: Particles and Fields, 2000, 12, pp.209-224. ⟨10.1007/s100529900227⟩. ⟨in2p3-00003675⟩

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