Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Nabil Ghodbane. Recherche de sélectrons et de smuons dans l'expérience DELPHI au LEP. Physique des Hautes Energies - Expérience [hep-ex]. Université Claude Bernard - Lyon I, 2000. Français. ⟨NNT : ⟩. ⟨tel-00001412⟩
  • Emmanuel Benichou, Abdul-Rahman Allouche, Rodolphe Antoine, Monique Aubert-Frecon, Mickaël Bourgoin, et al.. Non perturbative approach for a polar and polarizable linear molecule in an inhomogeneous electric field: Application to molecular beam deviation experiments. The European Physical Journal D : Atomic, molecular, optical and plasma physics, 2000, 10 (2), pp.233-242. ⟨10.1007/s100530050544⟩. ⟨hal-00492376⟩
  • S. Katsanevas, P. Verdier. Search for Gluino from stop decay. Rencontres de Moriond : Interactions Electrofaibles et Theories Unifiees 35, Mar 2000, Les Arcs, France. ⟨in2p3-00011065⟩
  • R. Barbier, P. Jonsson, V. Poireau. Search for R-parity violation with a \bar{U} \bar{D} \bar{D} coupling at \sqrt{s}= 192 - 202 GeV. Rencontres de Moriond : Interactions Electrofaibles et Theories Unifiees 35, Mar 2000, Les Arcs, France. ⟨in2p3-00011060⟩
  • M. Bajard, J. Remillieux, A. Demeyer. L'hadrontherapie par faisceau d'ions carbone. Symposium sur l'Hadrontherapie par Faisceau d'Ions Carbone, Mar 2000, Lyon, France. ⟨in2p3-00011618⟩
  • P. Jonsson. R-parity violating SUSY with the DELPHI detector. Les Rencontres de physique de la Vallee d'Aoste : Results and Perspectives in Particle Physics, Feb 2000, La Thuile, Italy. ⟨in2p3-00005720⟩
  • G. Chardin, B. Chambon, M. de Jésus, D. Drain, J. Gascon, et al.. Event categories in EDELWEISS : a simple interpretation of the anomalous NaI events. International Symposium on Sources and Detection of Dark Matter in the Universe 4, Feb 2000, Marina Del Rey, United States. ⟨in2p3-00007820⟩
  • J. Delorme, M. Ericson, P.A.M. Guichon, A.W. Thomas. Mass reduction as signal of chiral symmetry restoration. International Conference on Quark Nuclear Physics 2000 - QNP 2000, Feb 2000, Adelaide, Australia. pp.250c-253c. ⟨in2p3-00008426⟩
  • G. Grenier. Search at LEP for \bar \chi^{\pm}_1 mass degenerate with the \bar \chi^{0}_1. Lake Louise Winter Institute, Feb 2000, Lake Louise,Alberta, United States. pp.265-277. ⟨in2p3-00009732⟩
  • R. Planeta, W. Gawlikowicz, A. Wieloch, J. Brzychczyk, T. Ciszek, et al.. Properties of projectile-like fragments from the ^{40}Ca + ^{40}Ca reaction at 35 MeV/nucleon. 2000. ⟨in2p3-00005277⟩

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