Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • D. Davesne, A. Pastore, J. Navarro. Linear response theory in asymmetric nuclear matter for Skyrme functionals including spin-orbit and tensor terms II: Charge Exchange. Phys.Rev.C, 2019, 100 (6), pp.064301. ⟨10.1103/PhysRevC.100.064301⟩. ⟨hal-02160618⟩
  • Rebecca Meissner, Linda Feketeová, Andreas Bayer, Johannes Postler, Paulo LimĂŁo-Vieira, et al.. Positive and negative ions of the amino acid histidine formed in low-energy electron collisions. J.Mass Spectrom., 2019, 54 (10), pp.802-816. ⟨10.1002/jms.4427⟩. ⟨hal-02431409⟩
  • A. Abada, M. Abbrescia, S.S. Abdussalam, I. Abdyukhanov, J. Abelleira Fernandez, et al.. FCC-hh: The Hadron Collider. Eur.Phys.J.ST, 2019, 228 (4), pp.755-1107. ⟨10.1140/epjst/e2019-900087-0⟩. ⟨hal-02279032⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of associated production of a W boson and a charm quark in proton-proton collisions at \sqrt{s} = 13 TeV. European Physical Journal C: Particles and Fields, 2019, 79 (3), pp.269. ⟨10.1140/epjc/s10052-019-6752-1⟩. ⟨hal-01952816⟩
  • Alexandre Arbey, JĂ©rĂ©my Auffinger. BlackHawk: A public code for calculating the Hawking evaporation spectra of any black hole distribution. Eur.Phys.J.C, 2019, 79 (8), pp.693. ⟨10.1140/epjc/s10052-019-7161-1⟩. ⟨hal-02144274⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Observation of prompt J/\psi meson elliptic flow in high-multiplicity pPb collisions at \sqrt{s_\mathrm{NN}} = 8.16 TeV. Physics Letters B, 2019, 791, pp.172-194. ⟨10.1016/j.physletb.2019.02.018⟩. ⟨hal-01897241⟩
  • Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of differential cross sections for Z boson pair production in association with jets at \sqrt{s} = 8 and 13 TeV. Physics Letters B, 2019, 789, pp.19-44. ⟨10.1016/j.physletb.2018.11.007⟩. ⟨hal-01839706⟩
  • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Dielectron and heavy-quark production in inelastic and high-multiplicity proton–proton collisions at \sqrt {s_{NN}}= 13TeV. Physics Letters B, 2019, 788, pp.505-518. ⟨10.1016/j.physletb.2018.11.009⟩. ⟨hal-01801865⟩
  • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. \Upsilon suppression at forward rapidity in Pb-Pb collisions at \sqrt{s_{\rm NN}} = 5.02 TeV. Physics Letters B, 2019, 790, pp.89-101. ⟨10.1016/j.physletb.2018.11.067⟩. ⟨hal-01801861⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of prompt \psi(2S) production cross sections in proton-lead and proton-proton collisions at \sqrt{s_{_\mathrm{NN}}}= 5.02 TeV. Physics Letters B, 2019, 790, pp.509-532. ⟨10.1016/j.physletb.2019.01.058⟩. ⟨hal-01797218⟩

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