Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • N.A. Webb, D. Leahy, S. Guillot, N. Baillot d'Etivaux, D. Barret, et al.. Thermal X-ray emission identified from the millisecond pulsar PSR J1909–3744. Astronomy & Astrophysics - A&A, 2019, 627, pp.A141. ⟨10.1051/0004-6361/201732040⟩. ⟨hal-02193933⟩
    • Chen Chris Gong, Noam I. Libeskind, Elmo Tempel, Quan Guo, Stefan Gottlöber, et al.. The Origin of Lopsided Satellite Galaxy Distribution in Galaxy Pairs. Monthly Notices of the Royal Astronomical Society, 2019, 488 (3), pp.3100-3108. ⟨10.1093/mnras/stz1917⟩. ⟨hal-02272667⟩
    • H. Abdoul-Carime, Franck Rabilloud. Selective Desorption of Ethylene after Dimethyl Sulfide Reaction on Cold Gold Surface. J.Phys.Chem.C, 2019, 123 (3), pp.1874-1879. ⟨10.1021/acs.jpcc.8b11311⟩. ⟨hal-01998998⟩
    • M. Baldo, C. Ducoin. Coupling between superfluid neutrons and superfluid protons in the elementary excitations of neutron star matter. Physical Review C, 2019, 99 (2), pp.025801. ⟨10.1103/PhysRevC.99.025801⟩. ⟨hal-02008820⟩
    • Jonathan Chardin, GrĂ©goire Uhlrich, Dominique Aubert, Nicolas Deparis, Nicolas Gillet, et al.. A deep learning model to emulate simulations of cosmic reionization. Monthly Notices of the Royal Astronomical Society, 2019, 490 (1), pp.1055-1065. ⟨10.1093/mnras/stz2605⟩. ⟨hal-02148238⟩
    • Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. ^3_\Lambda\mathrm{H} and ^3_{\bar{\Lambda}}\mathrm{\overline{H}} lifetime measurement in Pb-Pb collisions at \sqrt{s_{\mathrm{NN}}} = 5.02 TeV via two-body decay. Physics Letters B, 2019, 797, pp.134905. ⟨10.1016/j.physletb.2019.134905⟩. ⟨hal-02279093⟩
    • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, et al.. Jet fragmentation transverse momentum measurements from di-hadron correlations in \sqrt{s} = 7 TeV pp and \sqrt{s_{\rm{NN}}} = 5.02 TeV p-Pb collisions. Journal of High Energy Physics, 2019, 03, pp.169. ⟨10.1007/JHEP03(2019)169⟩. ⟨hal-01952963⟩
    • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Dielectron and heavy-quark production in inelastic and high-multiplicity proton–proton collisions at \sqrt {s_{NN}}= 13TeV. Physics Letters B, 2019, 788, pp.505-518. ⟨10.1016/j.physletb.2018.11.009⟩. ⟨hal-01801865⟩
    • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. \Upsilon suppression at forward rapidity in Pb-Pb collisions at \sqrt{s_{\rm NN}} = 5.02 TeV. Physics Letters B, 2019, 790, pp.89-101. ⟨10.1016/j.physletb.2018.11.067⟩. ⟨hal-01801861⟩
    • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, et al.. Calibration of the photon spectrometer PHOS of the ALICE experiment. Journal of Instrumentation, 2019, 14 (05), pp.P05025. ⟨10.1088/1748-0221/14/05/P05025⟩. ⟨hal-02058538⟩

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