Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • P. Abreu, W. Adam, T. Adye, P. Adzic, Z. Albrecht, et al.. Measurement of V_{cb} from the decay process \bar{B^0} - D^{*+} \ell^- \bar{\nu}. Physics Letters B, 2001, 510, pp.55-74. ⟨10.1016/S0370-2693(01)00569-X⟩. ⟨in2p3-00008930⟩
  • F. Gobet, B. Farizon, M. Farizon, M.J. Gaillard, J.P. Buchet, et al.. Probing the liquid-t-gas like phase transition in a cluster via a caloric curve. Physical Review Letters, 2001, 87, pp.203401. ⟨in2p3-00010403⟩
  • N. Falletto, M. Authier, G. Bardin, Maud Baylac, M. Boyer, et al.. Compton scattering off polarized electrons with a high finess Fabry-Perot cavity at JLab. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2001, 459, pp.412-425. ⟨10.1016/S0168-9002(00)01049-4⟩. ⟨in2p3-00009719⟩
  • P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, G. Alemanni, et al.. Search for Heavy Isosinglet Neutrino in e^+ e^- Annihilation at LEP. Physics Letters B, 2001, 517, pp.67-74. ⟨in2p3-00010108⟩
  • Alain Benoit, L. Berge, A. Broniatowski, B. Chambon, M. Chapellier, et al.. First Results of the EDELWEISS WIMP Search using a 320 g Heat-and-Ionization Ge Detector. Physics Letters B, 2001, 513, pp.15-22. ⟨hal-00009203⟩
  • X. Artru, P. Rullhusen. Parametric X-rays and diffracted transition radiation in perfect and mosaic crystals - Addentum NIM B145 (1998) 1. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2001, 173, ⟨10.1016/S0168-583X(00)00075-6⟩. ⟨in2p3-00008334⟩
  • G. Moret, L. Chaussard, Y. Déclais, S. Katsanevas, P. Jonsson, et al.. Brick finding efficiency : Monte Carlo comparisons between several scintillating tracker options. 2001, pp.20. ⟨in2p3-00009260⟩
  • P. Desgrolard, M. Giffon, E. Martynov. Rescattering corrections in elastic scattering. Journal of High Energy Physics, 2001, 5, pp.024. ⟨in2p3-00009908⟩
  • R. Planeta, Z. Sosin, P. Hachaj, T. Ciszek, W. Gawlikowicz, et al.. The intermediate velocity source in the ^{40}Ca + ^{197}Au reaction at 35 AMeV. Acta Physica Polonica B, 2001, 32, pp.3079-3097. ⟨in2p3-00010588⟩
  • M. Daoud, M. Kibler. Variations on a theme of quons: II. - a fractional supersymmetric oscillator. Recent Results Development on Quantum Chemistry, Trans Tech Publications, pp.101-110, 2001. ⟨in2p3-00011319⟩

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