Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • J.D. Frankland, Ch.O. Bacri, B. Borderie, M.F. Rivet, M. Squalli, et al.. Multifragmentation of a very heavy nuclear system (I): selection of a single-source events. Nuclear Physics A, 2001, 689, pp.905-939. ⟨10.1016/S0375-9474(00)00606-0⟩. ⟨in2p3-00009773⟩
  • F. Lavaud, E. Plagnol, G. Auger, Ch-O. Bacri, M-L. Begemann-Blaich, et al.. Nuclear multifragmentation and the onset of radial flow: a study of Au+Au collisions between 40 and 100 MeV/A. International Nuclear Physics Conference: Nuclear Physics in the 21st Century INPC 2001, 2001, Berkeley, United States. pp.716-720, ⟨10.1063/1.1470022⟩. ⟨in2p3-00011888⟩
  • P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, G. Alemanni, et al.. Search for Heavy Neutral and Charged Leptons in e^+ e^- Annihilation at LEP. Physics Letters B, 2001, 517, pp.75-85. ⟨10.1016/S0370-2693(01)01005-X⟩. ⟨in2p3-00010109⟩
  • D. Teyssier. A flavour-independent search for a hadronically decaying neutral Higgs bosons at LEP with the L3 detector. International Journal of Modern Physics A, 2001, 16, pp.819-821. ⟨10.1142/S0217751X01008199⟩. ⟨in2p3-00008021⟩
  • M. Bajard, J. Remillieux. Projet d'un centre d'hadrontherapie par faisceaux d'ions carbone a Lyon. Cahiers de Radiobiologie, 2001, 12. ⟨in2p3-00011672⟩
  • M. Chemarin, H. El Mamouni, J. Fay, G. Grenier, I. Laktineh, et al.. Search for scalar quarks in e^+e^- collisions at \sqrt{s} = 202-208 GeV. International Europhysics Conference on High Energy Physics European Physical Society EPS HEP 2001, 2001, Budapest, Hungary. ⟨in2p3-00010721⟩
  • M. Kibler. Elements de mathematiques pour la physique et la chimie - avec 230 exemples et 230 exercices et problemes. Editions Scientifiques GB, pp.353, 2001. ⟨in2p3-00010644⟩
  • M. Chemarin, H. El Mamouni, J. Fay, G. Grenier, I. Laktineh, et al.. Single and multi-photon events with missing energy in e^+e^- collisions at \sqrt{s} = 202-208 GeV. International Europhysics Conference on High Energy Physics European Physical Society EPS HEP 2001, 2001, Budapest, Hungary. ⟨in2p3-00010719⟩
  • P. Desgrolard. Space structure of hadrons in elastic scattering at high energy. Journal of High Energy Physics, 2001, 7, pp.005. ⟨in2p3-00009922⟩
  • X. Artru, Guillaume Bignon, Taoufik Qasmi. Side-slipping of a radiating particle. Problems of Atomic Science and Technology, 2001, 6, pp.98-102. ⟨hal-00010133⟩

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