Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8788 documents

  • A. Bauchet, I. Deloncle, M.G. Porquet, A. Astier, N. Buforn, et al.. First identification of rotational bands in ^{103}Tc: evolution of intrinsic proton states of the ^{97-105}_{43}Tc isotopes. The European physical journal. A, Hadrons and Nuclei, 2001, 10, pp.145-150. ⟨in2p3-00009897⟩
  • P. Abreu, W. Adam, T. Adye, P. Adzic, I. Ajinenko, et al.. Single Intermediate Vector Boson Production in e^+ e^- collisions at \sqrt{s} = 183 and 189 GeV. Physics Letters B, 2001, 515, pp.238-254. ⟨10.1016/S0370-2693(01)00807-3⟩. ⟨in2p3-00010372⟩
  • P. Abreu, W. Adam, T. Adye, P. Adzic, I. Azhinenko, et al.. Search for neutralino pair production at \sqrt{s} = 189 GeV. European Physical Journal C: Particles and Fields, 2001, 19, pp.201-212. ⟨10.1007/s100520100615⟩. ⟨in2p3-00008011⟩
  • M. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, et al.. Centrality states suppression and transverse momentum distribution in Pb-Pb collisions at the CERN SPS. International Symposium on Multiparticle Dynamics, ISMD2001, 2001, Datong, China. ⟨in2p3-00011668⟩
  • A. Deandrea, R. Gatto, G. Nardulli, A.D. Polosa, N.A. Toernqvist. The s\bar s and K\bar K nature of f_0(980) in D_s decays. Physics Letters B, 2001, 502, pp.79-86. ⟨in2p3-00009821⟩
  • P. Desgrolard, E. Martynov. Regge models of the proton structure function with and without hard Pomeron - A comparative analysis. European Physical Journal C: Particles and Fields, 2001, 22, pp.479-492. ⟨in2p3-00011643⟩
  • M. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, et al.. Charmonia states suppression and transverse momentum distribution in Pb-Pb collisions at the CERN SPS. International Workshop on QCD Theory and Experiment, 2001, Martina Franca, Italy. ⟨in2p3-00011667⟩
  • P. Abreu, W. Adam, T. Adye, P. Adzic, Z. Albrecht, et al.. Measurement of trilinear gauge boson couplings WWV (V\equiv \gamma,Z) in e^+ e^- collisions at 189 GeV. Physics Letters B, 2001, 502, pp.9-23. ⟨10.1016/S0370-2693(01)00135-6⟩. ⟨in2p3-00008393⟩
  • M. Novello, J.M. Salim, V.A. de Lorenci, E. Elbaz. Nonlinear electrodynamics can generate a closed spacelike path for photons. Physical Review D, 2001, 63, pp.103516-1-103516-5. ⟨in2p3-00009399⟩
  • G. Hadinger. Etude du deuxieme spectrometre de masse pour l'analyse des fragments d'ADN produits apres intersection avec un faisceau de protons. 2001. ⟨in2p3-00010018⟩

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