Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- T. Fiegele, G. Hanel, M. Rummele, B. Gstir, M. Lezius, et al.. High resolution electron ionization study of atoms and clusters: appearance energies. Symposium on Applied Plasma Physics - SAPP 2001, Jan 2001, Bratislava, Slovakia. ⟨in2p3-00010742⟩
- M. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, et al.. Enhancement of intermediate mass dimuons in nucleus nucleus collisions at the CERN SPS. International Conference on Ultrarelativistic Nucleus-Nucleus Collisions - QM2001 15, Jan 2001, Stony Brook, United States. pp.539c-542c. ⟨in2p3-00013578⟩
- M. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, et al.. Charmonia suppression in p-A collisions at 450 GeV/c : new results from NA50. Quark Matter 2001 15, Jan 2001, Long Island, United States. pp.543c-546c. ⟨in2p3-00010996⟩
- Rachid Guernane. Optimisation du spectromètre à muons du détecteur ALICE pour l'étude du plasma de quarks et de gluons au LHC. Physique Nucléaire Théorique [nucl-th]. Université Claude Bernard - Lyon I, 2001. Français. ⟨NNT : ⟩. ⟨tel-00001419⟩
- Nadège Buforn. Force de Coriolis et déformation nucléaire : résultats dans les isotopes de cadmium et de plomb avec le multidétecteur gamma EUROBALL. Physique Nucléaire Théorique [nucl-th]. Université Claude Bernard - Lyon I, 2001. Français. ⟨NNT : ⟩. ⟨tel-00001418⟩
- M. Chemarin, H. El Mamouni, J. Fay, G. Grenier, I. Laktineh, et al.. Search for production of neutral Higgs scalars in e
e
annihilations at LEP. International Europhysics Conference on High Energy Physics European Physical Society EPS HEP 2001, 2001, Budapest, Hungary. ⟨in2p3-00010717⟩ - A.K. Raina, J.-M. Richard. Rearrangement of levels in exotic atoms. 2001, pp.6. ⟨in2p3-00011142⟩
- M. Kibler, M. Daoud. Variations on a theme of quons: I. - a non standard basis for the Wigner-Racah algebra of the group SU(2). Recent Results Development on Quantum Chemistry, Trans Tech Publications, pp.91-99, 2001. ⟨in2p3-00011318⟩
- X. Artru, David Fayolle. Dynamics of a magnetic monopole in matter, Maxwell equations in dyonic matter and detection of electric dipole moments. Problems of Atomic Science and Technology, 2001, 6, pp.110-114. ⟨hal-00010135⟩
- G. de Angelis, S. Brandenburg, Ph. Dessagne, J.P. Gatesoupe, W. Gelletly, et al.. SPIRAL II : Preliminary design study. [Research Report] GANIL. 2001. ⟨in2p3-00263535⟩
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