Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • W. Ryssens, M. Bender, K. Bennaceur, P.-H. Heenen, J. Meyer. Impact of the surface energy coefficient on the deformation properties of atomic nuclei as predicted by Skyrme energy density functionals. Phys.Rev.C, 2019, 99 (4), pp.044315. ⟨10.1103/PhysRevC.99.044315⟩. ⟨hal-01885860⟩
  • Justin H. Robinson, Misty C. Bentz, Megan C. Johnson, HĂ©lène M. Courtois, Benjamin Ou-Yang. H i Spectroscopy of Reverberation-mapped Active Galactic Nuclei. The Astrophysical Journal, 2019, 880 (2), pp.68. ⟨10.3847/1538-4357/ab29f9⟩. ⟨hal-02447923⟩
  • B. Liu, D. Liu, Q. Shen, T. Zhang, G. Garillot, et al.. Energy reconstruction for a hadronic calorimeter using multivariate data analysis methods. JINST, 2019, 14 (10), pp.P10034. ⟨10.1088/1748-0221/14/10/P10034⟩. ⟨hal-02393086⟩
  • D.A. Noreña, J.C. Muñoz-Cuartas, L.F. Quiroga, N. Libeskind. Substructures in Minor Mergers' Tidal Streams. Rev.Mex.Astron.Astrofis., 2019, 55, pp.273-288. ⟨10.22201/ia.01851101p.2019.55.02.14⟩. ⟨hal-02431435⟩
  • Robin Terrisse, Dimitrios Tsimpis. Consistent truncation with dilatino condensation on nearly Kähler and Calabi-Yau manifolds. Journal of High Energy Physics, 2019, 02, pp.088. ⟨10.1007/JHEP02(2019)088⟩. ⟨hal-01909241⟩
  • Robin Terrisse, Dimitrios Tsimpis. Consistent truncation and de Sitter space from gravitational instantons. Journal of High Energy Physics, 2019, 07, pp.034. ⟨10.1007/JHEP07(2019)034⟩. ⟨hal-02097301⟩
  • P. Delahaye, G. Ban, M. Benali, D. Durand, X. Fabian, et al.. The open LPC Paul trap for precision measurements in beta decay. The European physical journal. A, Hadrons and Nuclei, 2019, 55 (6), pp.101. ⟨10.1140/epja/i2019-12777-3⟩. ⟨hal-01902850⟩
  • J.M. Pearson, N. Chamel, A.Y. Potekhin, A.F. Fantina, C. Ducoin, et al.. Erratum: Unified equations of state for cold non-accreting neutron stars with Brussels-Montreal functionals. I. Role of symmetry energy. Monthly Notices of the Royal Astronomical Society, 2019, 486 (1), pp.768. ⟨10.1093/mnras/stz800⟩. ⟨hal-03199990⟩
  • Rebecca Meissner, Linda Feketeová, Eugen Illenberger, Stephan Denifl. Reactions in the Radiosensitizer Misonidazole Induced by Low-Energy (0–10 eV) Electrons. Int.J.Mol.Sc., 2019, 20 (14), pp.3496. ⟨10.3390/ijms20143496⟩. ⟨hal-02277850⟩
  • Jessica Garcia, David Barthelemy, Florence Geiguer, Julie Ballandier, Kathryn Li, et al.. Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence. Journal of visualized experiments : JoVE, 2019, 150, pp.e59873. ⟨10.3791/59873⟩. ⟨hal-03133165⟩

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