Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8788 documents

  • F. Gobet, B. Farizon, M. Farizon, M.J. Gaillard, M. Carre, et al.. Ionization of water vapor induced by 20-150 keV protons: direct ionization and electron capture. European Conference on Atomic and Molecular Physics 7 ECAMP VII, Apr 2001, Berlin, Germany. ⟨in2p3-00011051⟩
  • M. Farizon, F. Gobet, B. Farizon, M.J. Gaillard, J.P. Buchet, et al.. Multifragmentation of molecular cluster and percolation transition: a quantitative. 7th European Conference on Atomic and Molecular Physics - ECAMP VII, Apr 2001, Berlin, Germany. ⟨in2p3-00010737⟩
  • M. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, et al.. The Npart dependence of the anomalous J/\psi suppression in Pb-Pb collisions at the CERN SPS. Rencontres de Moriond ``QCD and Hadronic Interactions'' 36, Mar 2001, Les Arcs, France. ⟨in2p3-00012201⟩
  • S. Katsanevas, P. Verdier. Search for and LSP Gluino at LEP. Rencontres de Moriond on QCD and High Energy Hadronic Interactions 36, Mar 2001, Les Arcs, France. ⟨in2p3-00011061⟩
  • Laurent Capelli. Etude des dimuons de la région des masses intermédiaires produits dans les collisions d'ions lourds auprès du SPS du CERN. Physique des Hautes Energies - Expérience [hep-ex]. Université Claude Bernard - Lyon I, 2001. Français. ⟨NNT : 2001LYO10009⟩. ⟨tel-00000001⟩
  • O. Martineau. Direct and indirect detection of WIMPs. Rencontres de Physique de la Vallee d'Aoste 15, Mar 2001, La Thuile, Italy. pp.1-12. ⟨in2p3-00010569⟩
  • D. Bouvet, V. Chorowicz, D. Contardo, R. Haroutunian, L. Mirabito, et al.. Behaviour of Small Gap plus GEM chambers in close LHC conditions. Vienna Conference on Instrumentation 9, Feb 2001, Vienne, Austria. pp.267-270, ⟨10.1016/S0168-9002(01)01769-7⟩. ⟨in2p3-00019750⟩
  • L. Chaussard, G. Moret. Brick finding efficiency using scintillators information for single charged particles. 2001. ⟨in2p3-00008136⟩
  • M-C. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, et al.. J/\psi,\psi' and DY production in proton nucleus collisions at 450 GeV incident energy at the NA50 experiment. International Winter Meeting on Nuclear Physics 39, Jan 2001, Bormio, Italy. pp.304-315. ⟨in2p3-00009530⟩
  • B. Bouriquet, J.P. Wieleczko, A.S. Botvina, S. Salou, G. Auger, et al.. Experimental signatures of non spherical single sources produced in central Xe+Sn collisions at 32 MeV/nucleon. International Winter Meeting of Nuclear Physics 39, Jan 2001, Bormio, Italy. pp.84-102. ⟨in2p3-00009932⟩

Powered by HAL logo