Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8788 documents

  • R. Barbier. R-parity violation searches at LEP. International Conference on Supersymetry and Unification of Fundamental Interactions 9 SUSY'01, Jul 2001, Dubna, Russia. pp.87-90. ⟨in2p3-00012218⟩
  • F. Acernese, P. Amico, N. Arnaud, C. Arnault, D. Babusci, et al.. The present status of the VIRGO Central Interferometer. Edoardo Amaldi conference on gravitational waves 4, Jul 2001, Perth, Australia. pp.1421-1428. ⟨in2p3-00011458⟩
  • M. Daoud, M. Kibler. Fractional supersymmetric quantum mechanics. 9th International Conference on Symmetry Methods in Physics, Jul 2001, Yerevan, Armenia. pp.S43-S51. ⟨in2p3-00012617⟩
  • Abdelhamid Rabhi, P. Schuck, R. Bennaceur, G. Chanfray, J. Dukelsky. Restoration of broken symmetries in Self-Consistent RPA. 2001. ⟨in2p3-00009938⟩
  • X. Artru, G. Bignon. A semiclassical approach to the radiation damping force. NATO Advanced Research Workshop on Electron Photon Interaction in Dense Media, Jun 2001, Nor Hamberd, Armenia. pp.85-90. ⟨in2p3-00011185⟩
  • J. Remillieux. Projet Rhone-Alpes d'hadrontherapie par ions legers (partie scientifique). Colloque International de Radiobiologie Fondamentale et Appliquee 5, Jun 2001, Autrans, France. ⟨in2p3-00011677⟩
  • D. Drain, A. Bonnevaux, B. Chambon, P. Cluzel, M. de Jésus, et al.. The EDELWEISS experiment status. Rencontres de Blois 13, Jun 2001, Blois, France. ⟨in2p3-00010566⟩
  • A. Deandrea. A quark loop model for heavy mesons. QCD Work, Jun 2001, Martina Franca, Italy. pp.6. ⟨in2p3-00010402⟩
  • Franck Gobet. Fragmentation de molécules et d'agrégats moléculaires induite par collision avec un atome à haute vitesse (vitesse relative de l'ordre de c/100). Physique des Hautes Energies - Expérience [hep-ex]. Université Claude Bernard - Lyon I, 2001. Français. ⟨NNT : ⟩. ⟨tel-00001427⟩
  • B. Tellili. Search for charginos and neutralinos at LEP. International Conference on Supersymmetry and Unification on Fundamental Interactions 9 SUSY'01, Jun 2001, Dubna, Russia. pp.28-35. ⟨in2p3-00012217⟩

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