Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8788 documents

  • N. Cue, D. Dauvergne, M. Fallavier, R. Kirsch, J.-C. Poizat, et al.. Channeling of fast Pb^{56+} ions in a thin silicon crystal: simultaneous measurements of energy loss charge exchange and secondary electron emission. International Conference on Atomic Collisions in Solids 19, Jul 2001, Paris, France. ⟨in2p3-00010704⟩
  • F. Barrué, S. Basnary, A. Chbihi, M. Chevallier, C. Cohen, et al.. Nuclear fission time measurements as a function of excitation energy - A crystal blocking experiment. XIX International Conference on Atomic Collisions in Solids ICAS, Jul 2001, Paris, France. pp.852-859, ⟨10.1016/S0168-583X(02)00915-1⟩. ⟨in2p3-00012224⟩
  • N. Cue, D. Dauvergne, M. Fallavier, R. Kirsch, J.-C. Poizat, et al.. Proton channeling in carbon nanotubes. International Conference on Atomic Collisions in Solids 9, Jul 2001, Paris, France. ⟨in2p3-00010703⟩
  • X-F. Navick, O. Martineau, M. de Jésus, J. Gascon. 320g ionization heat cryogenic detector for dark matter search in the EDELWEISS experiment. Low Temperature Detectors 9, Jul 2001, Madison, United States. pp.505-508. ⟨in2p3-00011661⟩
  • X.F. Navick, Angélique Benoit, L. Bergé, A. Broniatowski, B. Chambon, et al.. Dark matter search in the EDELWEISS experiment using a 320 g ionization-heat Ge-detector. Low Temperature Detectors International Workshop on Low Temperature Detectors 9, Jul 2001, Madison, United States. pp.489-492. ⟨in2p3-00013630⟩
  • M. Chemarin, H. El Mamouni, J. Fay, G. Grenier, I. Laktineh, et al.. Search for the neutral Higgs bosons of the minimal supersymmetric Standard Model in e^+e^- interactions in center-of-mass energies up to 209 GeV at LEP. International Europhysics Conference on High Energy Physics European Physical Society EPS HEP 2001, Jul 2001, Budapest, Hungary. ⟨in2p3-00010713⟩
  • S. Katsanevas, P. Verdier. Search for and LSP Gluino at LEP. International Europhysics Conference on High Energy Physics European Physical Society EPS HEP 2001, Jul 2001, Budapest, Hungary. ⟨in2p3-00011063⟩
  • M. Chemarin, H. El Mamouni, J. Fay, G. Grenier, I. Laktineh, et al.. Search for charginos and neutralinos in e^+e^- collisions at \sqrt{s} = 202-208 GeV. International Europhysics Conference on High Energy Physics European Physical Society EPS HEP 2001, Jul 2001, Budapest, Hungary. ⟨in2p3-00010718⟩
  • R. Barate, M. Chemarin, H. El Mamouni, J. Fay, G. Grenier, et al.. Search for the Standard Model Higgs boson at LEP. International Europhysics Conference on High Energy Physics European Physical Society EPS HEP 2001, Jul 2001, Budapest, Hungary. ⟨in2p3-00010732⟩
  • M. Chemarin, H. El Mamouni, J. Fay, G. Grenier, I. Laktineh, et al.. Search for the Standard Model Higgs boson in e^+e^- collisions at center-of-mass energies up to 209 GeV at LEP. International Europhysics Conference on High Energy Physics European Physical Society EPS HEP 2001, Jul 2001, Budapest, Hungary. ⟨in2p3-00010714⟩

Powered by HAL logo