Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8788 documents

  • N. Bérerd, H. Catalette, A. Chevarier, N. Chevarier, H. Faust, et al.. Zirconium surface modification under fission product irradiation - Application to nuclear fuel cladding tubes. Conference on Surface Modifications of Materials by Ion Beams - SMMIB 2001, Sep 2001, Marburg, Germany. pp.473-476. ⟨in2p3-00011673⟩
  • N. Bérerd. Zirconium surface modification under fission product irradiation. Application to nuclear fuel cladding tubes. 12th International Conference on Surface Modification of Materials by Ion Beams (SMMIB), Sep 2001, Marburg, Germany. 2001. ⟨in2p3-00024732⟩
  • O. Martineau, Angélique Benoit, L. Bergé, R. Bouvier, A. Broniatowski, et al.. Dark matter search in the EDELWEISS experiment. International Workshop on Topics in Astroparticle and Underground Physics 7 TAUP 2001, Sep 2001, Assergi(L'Aquila), Italy. pp.70-72. ⟨in2p3-00011969⟩
  • C.E. Aalseth, E. Arik, D. Autiero, F.T. Avigone, K. Barth, et al.. The CERN axion solar telescope (CAST). Topics in Astroparticle and Underground Physics - TAUP 2001, Sep 2001, Assergi, Italy. pp.85-87. ⟨in2p3-00020266⟩
  • G. Chanfray. Low mass dilepton production and chiral symmetry restoration. International Workshop on the Physics of the Quark Gluon Plasma, Sep 2001, Palaiseau, France. ⟨in2p3-00010646⟩
  • M.C. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, et al.. Centrality behaviour of J/\psi production in NA50. International Symposium on Multiparticle Dynamics 31, Sep 2001, Datong, China. pp.127-131. ⟨in2p3-00011890⟩
  • S. Katsanevas. Supersymetry : the legacy of LEP. Delphi Workshop, Sep 2001, Delphes, Greece. ⟨in2p3-00010675⟩
  • M. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, et al.. Latest results from Na50 on J/\psi suppression in Pb-Pb collisions at 158 GeV/c. International Nuclear Physics Conference INPC 2001, Jul 2001, Berkeley, United States. ⟨in2p3-00012213⟩
  • M. Bureau, M. Cappellari, Y. Copin, E.K. Verolme, P.T. de Zeeuw, et al.. SAURON: An Innovative Look at Early-Type Galaxies. The Dynamics, Structure & History of Galaxies: A Workshop in Honour of Professor Ken Freeman., Jul 2001, Dunk Island, Australia. pp.53. ⟨in2p3-00024772⟩
  • N. Cue, D. Dauvergne, M. Fallavier, R. Kirsch, J.-C. Poizat, et al.. Channeling of fast Pb^{56+} ions in a thin silicon crystal: simultaneous measurements of energy loss charge exchange and secondary electron emission. International Conference on Atomic Collisions in Solids 19, Jul 2001, Paris, France. ⟨in2p3-00010704⟩

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