Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8788 documents

  • M. Oertel, M. Buballa, J. Wambach. Meson loop effects in the Nambu-Jona-Lasionio model. International Workshop on the Chiral Fluctuations in Hadronic Matter, Sep 2001, Orsay, France. pp.7. ⟨in2p3-00010668⟩
  • H. Hansen. Renormalized RPA in quantum field theory. International Workshop on the Chiral Fluctuations in Hadronic Matter, Sep 2001, Orsay, France. ⟨in2p3-00010671⟩
  • S. Lalkovski, A. Minkova, M.G. Porquet, T. Kutsarova, A. Bauchet, et al.. High-spin structures in ^{108,110}Pd isotopes produced in fusion/fission reactions. International school on nuclear physics, neutron physics and nuclear energy 14, Sep 2001, Varna, Bulgaria. pp.204-208. ⟨in2p3-00013688⟩
  • M. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, et al.. \phi and \rho + \omega vector-mesons produced in lead induced collisions. International Conference on Strange Quarks in Matter 6 SQM 2001, Sep 2001, Frankfurt, Germany. pp.1809-1817. ⟨in2p3-00011669⟩
  • K. Bennaceur. Results from shell model embedded in continuum calculations. Colloque GANIL 13, Sep 2001, Belgodere, France. ⟨in2p3-00010741⟩
  • J. Remillieux. Medical applications of heavy ions beams. Colloque GANIL 13, Sep 2001, Belgodere, France. ⟨in2p3-00011674⟩
  • B. Ille. Mechanism of additional losse of the limited light optically anisotropic scintillators like lead tungstate. International Conference on Inorganic Scintillators and their use in Scientific and Industrial Applications - SCINT 2000 6, Sep 2001, Chamonix, France. ⟨in2p3-00010518⟩
  • M. Fallavier, R. Kirsch, S.N. Morozov, J.-C. Poizat, J.-P. Thomas, et al.. Intense emission of cluster anions from gold targets under impact of keV/u gold clusters. Journées Françaises de Spectrométrie de Masse 18, Sep 2001, La Rochelle, France. 140102(R)(4 p.), ⟨10.1103/PhysRevB.68.140102⟩. ⟨in2p3-00013595⟩
  • A. Prévost. Pre-analyse des donnees brutes d'EUROBALL IV : logique floue et calibration. Ecole Internationale Joliot-Curie de Physique Nucleaire, Sep 2001, Maubuisson, France. ⟨in2p3-00010748⟩
  • N. Millard-Pinard, F. Brossard, N. Chevarier, A. Chevarier, D. Crusset, et al.. Retention capacities of zirconia and apatites towards iodine and technetium fission products. International Conference on Back-End of the Fuel Cycle : From Research to Solutions Global 2001, Sep 2001, Paris, France. pp.8. ⟨in2p3-00009261⟩

Powered by HAL logo