Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8788 documents

  • F. Wernli, E. Emssellem, Y. Copin. The remmant of a merger as revealed by OASIS/PUEO. Conference on "Galaxies: the Third Dimension", Dec 2001, Cozumel, Mexico. pp.270. ⟨in2p3-00024768⟩
  • T. Duguet, P. Bonche, P.-H. Heenen, J. Meyer. Pairing correlations. I. Description of odd nuclei in mean-field theories. Physical Review C, 2001, 65, pp.014310. ⟨10.1103/PhysRevC.65.014310⟩. ⟨cea-02928276⟩
  • T. Duguet, P. Bonche, P.-H. Heenen, J. Meyer. Pairing correlations. II. Microscopic analysis of odd-even mass staggering in nuclei. Physical Review C, 2001, 65, pp.014311. ⟨10.1103/PhysRevC.65.014311⟩. ⟨cea-02927984⟩
  • J. Remillieux. Carbon ion therapy : present status of the Rhone-Alpes project in Lyon. Med-AUSTRON Meeting, Dec 2001, Vienne, Austria. ⟨in2p3-00011675⟩
  • M. Combescure, D. Robert. A semiclassical approach in the linear response theory. Conference Internationale on Quantum Results in Mathematical Physics, Dec 2001, Taxco, Mexico. pp.83-88. ⟨in2p3-00012232⟩
  • O. Lopez, N. Bellaize, J.P. Wieleczko, G. Auger, B. Borderie, et al.. Probing the nuclear liquid-gas phase transition. International Workshop on Multifragmentation and related topics - IWM 2001, Nov 2001, Catania, Italy. pp.21-26. ⟨in2p3-00013652⟩
  • J.D. Frankland, R. Bougault, A. Chbihi, S. Hudan, A. Mignon, et al.. Universal fluctuations: a new approach to the study of phase transitions in intermediate energy heavy ion collisions. International Workshop on Multifragmentation and Related Topics, Nov 2001, Catania, Italy. pp.84-90. ⟨in2p3-00012233⟩
  • J.C. Steckmeyer, S. Aiello, A. Anzalone, G. Auger, M. Bini, et al.. Study of the dissipative binary channels in the ^{107}Ag + ^{58}Ni reaction at 52 MeV/nucleon. International Workshop on multifragmentation and related topics, Nov 2001, Catania, Italy. pp.176-180. ⟨in2p3-00013661⟩
  • A. Buta, J.C. Steckmeyer, G. Auger, C.O. Bacri, N. Bellaize, et al.. Towards an unambiguous determination of the excitation energy of the projectile in heavy-ion reactions ?. International Workshop on multifragmentation and related topics, Nov 2001, Catania, Italy. pp.192-196. ⟨in2p3-00013662⟩
  • J. Lukasik, W. Trautmann, F. Lavaud, E. Plagnol, G. Auger, et al.. AU+AU collisions at 40-150 mev/nucleon : from peripheral to central. International Workshop on multifragmentation and related topics, Nov 2001, Catania, Italy. pp.75-79. ⟨in2p3-00011904⟩

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