Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    540 documents

    • Janina Kopyra, Hassan Abdoul-Carime. Fragmentation of metal(II) bis(acetylacetonate) complexes induced by slow electrons. Beilstein J.Nanotechnol., 2023, 14, pp.980-987. ⟨10.3762/bjnano.14.81⟩. ⟨hal-04260493⟩
    • Wafa Bouleftour, Jean-Baptiste Guy, Pablo Moreno-Acosta, Claire Rodriguez Lafrasse, Paul Sargos, et al.. Challenges in radiobiology – technology duality as a key for a risk-free α/ÎČ ratio. Bulletin du Cancer, 2023, 110 (7-8), pp.768-775. ⟨10.1016/j.bulcan.2023.02.006⟩. ⟨hal-04170466⟩
    • Brent Huisman, Enrique Muñoz, Denis Dauvergne, Jean Michel LĂ©tang, David Sarrut, et al.. Analytical modeling and Monte Carlo simulations of multi-parallel slit and knife-edge slit prompt gamma cameras. Physics in Medicine and Biology, 2023, 68 (11), pp.115009. ⟨10.1088/1361-6560/acd237⟩. ⟨hal-04100094⟩
    • Florence Charlieux, Hassan Abdoul‐carime. Processes Induced by Electrons at Sub‐Ionization Energies Studied by the Correlated Ions‐(Ions/Neutrals) Mass Spectrometry. ChemPhysChem, 2023, 24 (8), pp.e202200722. ⟨10.1002/cphc.202200722⟩. ⟨hal-03960242⟩
    • Mario Alcocer-Ávila, Caterina Monini, Micaela Cunha, Étienne Testa, MichaĂ«l Beuve. Formalism of the NanOx biophysical model for radiotherapy applications. Frontiers in Physics, 2023, 11, pp.1011062. ⟨10.3389/fphy.2023.1011062⟩. ⟨hal-04518897⟩
    • H Abdoul-Carime, F Mounier, F Charlieux, H AndrĂ©. Correlated ion-(ion/neutral) time of flight mass spectrometer. Review of Scientific Instruments, 2023, 94 (4), pp.045104. ⟨10.1063/5.0141540⟩. ⟨hal-04088616⟩
    • M.E. Alcover-Avila, E. Testa, M. Beuve. Besoins et propositions pour la modelisation des effets biologiques des irradiations avec des ions de haute et basse energie. Workshop RadioTransNet: Recherche PrĂ©clinique en ProtonthĂ©rapie & HadronthĂ©rapie, Nov 2022, Caen, France. ⟨in2p3-04954471⟩
    • M. Beuve. Impacts de la prĂ©sence de nanoparticules sur les effets physiques, chimiques et biologiques induits par irradiations de photons: modĂ©lisation. GDR MI2B et le LabEx Primes organisent un colloque sur les nanoparticules en radiothĂ©rapie, Nov 2022, Clermont-Ferrand, France. ⟨in2p3-04955819⟩
    • C. Rodriguez-Lafrasse. CuPRiX : une nouvelle gĂ©nĂ©ration de nanoparticules combinant la chĂ©lation du cuivre et la radiosensibilisation pour le traitement des cancers radiorĂ©sistants et mĂ©tastatiques. GDR MI2B et le LabEx Primes organisent un colloque sur les nanoparticules en radiothĂ©rapie, Nov 2022, Clermont -Ferrand, France. ⟨in2p3-04955828⟩
    • D. Brichart-Vernos, M.-T. Aloy, J. Sidi-Boumedine, G. Ollier, O. Tillement, et al.. Evaluation de l'effet sensibilisant des nanoparticules AGuIX associees a une irradiation photonique dans un modele de chondrosarcome. GDR MI2B - Nanoparticules en radiotherapie et radiobiologie, Nov 2022, Clermont -Ferrand, France. ⟨in2p3-04956373⟩

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