Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8788 documents

  • P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, G. Alemanni, et al.. Search for a Higgs Boson Decaying into Two Photons at LEP. Physics Letters B, 2002, 534, pp.28-38. ⟨10.1016/S0370-2693(02)01572-1⟩. ⟨in2p3-00011424⟩
  • P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, G. Alemanni, et al.. Study of Multiphoton Final States and Tests of QED in e^+ e^- collisions at \sqrt{s} up to 209 GeV. Physics Letters B, 2002, 531, pp.28-38. ⟨10.1016/S0370-2693(02)01339-4⟩. ⟨in2p3-00011506⟩
  • M.C. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, et al.. Pseudorapidity distributions of charged particles as a function of centrality in Pb-Pb collisions at 158 and 40 GeV per nucleon incident energy. Physics Letters B, 2002, 530, pp.33-42. ⟨10.1016/S0370-2693(02)01352-7⟩. ⟨in2p3-00011381⟩
  • J.-Y. Grossiord, G. Jacquet, Yu. Margaryan. The RECLAM an optical transparent sensor for geometry alignment and monitoring systems. 2002, pp.9. ⟨in2p3-00011981⟩
  • N. Ghodbane, S. Katsanevas, I. Laktineh, J. Rosiek. Chargino searches at LEP for complex MSSM parameters. Nuclear Physics B, 2002, 647, pp.190-214. ⟨10.1016/S0550-3213(02)00944-6⟩. ⟨in2p3-00010674⟩
  • D. Bouvet, V. Chorowicz, D. Contardo, R. Haroutunian, L. Mirabito, et al.. Radiation hardness and ageing properties of Small Gap plus GEM Chambers. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2002, 485, pp.322-327. ⟨in2p3-00011646⟩
  • K. Bennaceur, J.F. Berger, B. Ducomet. Coupling to the continuous spectrum and HFB approximation. Nuclear Physics A, 2002, 708, pp.205-225. ⟨in2p3-00019896⟩
  • E.K. Verolme, M. Cappellari, Y. Copin, R.P. van Der Marel, R. Bacon, et al.. A SAURON study of M32 measuring the intrinsic flattening and the central black hole mass. Monthly Notices of the Royal Astronomical Society, 2002, 335, pp.517-525. ⟨10.1046/j.1365-8711.2002.05664.x⟩. ⟨in2p3-00012010⟩
  • R-D. Herzberg, N. Amzal, F. Becker, P.A. Butler, A.J.C. Chewter, et al.. Spectroscopy of tranferium nuclei: ^{252}No. Physical Review C, 2002, 65, pp.014303. ⟨in2p3-00020313⟩
  • A.G. Kim, C.W. Akerlof, G. Aldering, R. Amanullah, P. Astier, et al.. Wide-field surveys from the SNAP mission. Proceedings of SPIE, the International Society for Optical Engineering, 2002, 4836, pp.53-60. ⟨in2p3-00020386⟩

Powered by HAL logo