Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • E. Verstraelen, A. Teigelhöfer, W. Ryssens, F. Ames, A. Barzakh, et al.. Search for octupole-deformed actinium isotopes using resonance ionization spectroscopy. Phys.Rev.C, 2019, 100 (4), pp.044321. ⟨10.1103/PhysRevC.100.044321⟩. ⟨hal-02394734⟩
  • A. Kerbizi, X. Artru, Z. Belghobsi, A. Martin. Simplified recursive ^3P_0 model for the fragmentation of polarized quarks. Physical Review D, 2019, 100 (1), pp.014003. ⟨10.1103/PhysRevD.100.014003⟩. ⟨hal-02073501⟩
  • L. Kaya, A. Vogt, P. Reiter, M. Siciliano, N. Shimizu, et al.. Isomer spectroscopy in ^{133}Ba and high-spin structure of ^{134}Ba. Phys.Rev.C, 2019, 100 (2), pp.024323. ⟨10.1103/PhysRevC.100.024323⟩. ⟨hal-02296195⟩
  • Yves Le Gonidec, Marina Rosas-Carbajal, Jean de Bremond d'Ars, B. Carlus, J.-C Ianigro, et al.. Abrupt changes of hydrothermal activity in a lava dome detected by combined seismic and muon monitoring. Scientific Reports, 2019, 9 (1), pp.3079. ⟨10.1038/s41598-019-39606-3⟩. ⟨hal-01945011⟩
  • R. Arnaldi, K. Banicz, K. Borer, J. Castor, B. Chaurand, et al.. Nuclear dependence of light neutral meson production in p-A collisions at 400 GeV with NA60. European Physical Journal C: Particles and Fields, 2019, 79 (5), pp.443. ⟨10.1140/epjc/s10052-019-6848-7⟩. ⟨hal-02154290⟩
  • Thomas Carreau, Francesca Gulminelli, Jérôme Margueron. General predictions for the neutron star crustal moment of inertia. Phys.Rev.C, 2019, 100 (5), pp.055803. ⟨10.1103/PhysRevC.100.055803⟩. ⟨hal-01897180⟩
  • M. Martini, A. de Pace, K. Bennaceur. Spurious finite-size instabilities with Gogny-type interactions. The European physical journal. A, Hadrons and Nuclei, 2019, 55 (9), pp.150. ⟨10.1140/epja/i2019-12838-7⟩. ⟨hal-01823286⟩
  • E. Clement, M. de Mattia, S. Dutta, R. Eusebi, K. Hahn, et al.. A High-performance Track Fitter for Use in Ultra-fast Electronics. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2019, 935, pp.95-102. ⟨10.1016/j.nima.2019.05.018⟩. ⟨hal-01880795⟩
  • Ehsan Kourkchi, R. Brent Tully, J. Don Neill, Mark Seibert, Hélène M. Courtois, et al.. Global Attenuation in Spiral Galaxies in Optical and Infrared Bands. The Astrophysical Journal, 2019, 884 (1), pp.82. ⟨10.3847/1538-4357/ab4192⟩. ⟨hal-02431449⟩
  • S. Pandeti, L. Feketeová, T.J. Reddy, H. Abdoul-Carime, B. Farizon, et al.. Binding preference of nitroimidazolic radiosensitizers to nucleobases and nucleosides probed by electrospray ionization mass spectrometry and density functional theory. The Journal of Chemical Physics, 2019, 150 (1), pp.014302. ⟨10.1063/1.5062604⟩. ⟨hal-01991287⟩

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