Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Jean-Paul Ebran, Michael Bender, Nicolas Schunck, Thomas Duguet. Non-relativistic energy density functionals. Nicolas Schunck. Energy Density Functional Methods for Atomic Nuclei, IOP Publishing, pp.1-42, 2019, ⟨10.1088/2053-2563/aae0edch1⟩. ⟨hal-02883875⟩
    • D. Davesne, A. Pastore, J. Navarro. Linear response theory in asymmetric nuclear matter for Skyrme functionals including spin-orbit and tensor terms II: Charge Exchange. Physical Review C, 2019, 100 (6), pp.064301. ⟨10.1103/PhysRevC.100.064301⟩. ⟨hal-02160618⟩
    • H. Abdoul-Carime, Franck Rabilloud. Selective Desorption of Ethylene after Dimethyl Sulfide Reaction on Cold Gold Surface. J.Phys.Chem.C, 2019, 123 (3), pp.1874-1879. ⟨10.1021/acs.jpcc.8b11311⟩. ⟨hal-01998998⟩
    • Chen Chris Gong, Noam I. Libeskind, Elmo Tempel, Quan Guo, Stefan Gottlöber, et al.. The Origin of Lopsided Satellite Galaxy Distribution in Galaxy Pairs. Monthly Notices of the Royal Astronomical Society, 2019, 488 (3), pp.3100-3108. ⟨10.1093/mnras/stz1917⟩. ⟨hal-02272667⟩
    • N.A. Webb, D. Leahy, S. Guillot, N. Baillot d'Etivaux, D. Barret, et al.. Thermal X-ray emission identified from the millisecond pulsar PSR J1909–3744. Astronomy & Astrophysics - A&A, 2019, 627, pp.A141. ⟨10.1051/0004-6361/201732040⟩. ⟨hal-02193933⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Study of the {\mathrm{B}}^{+}\to \mathrm{J}/\psi \overline{\Lambda}\mathrm{p} decay in proton-proton collisions at \sqrt{s} = 8 TeV. JHEP, 2019, 12, pp.100. ⟨10.1007/JHEP12(2019)100⟩. ⟨hal-02277911⟩
    • Morad Aaboud, Georges Aad, Brad Abbott, Dale Charles Abbott, Ovsat Abdinov, et al.. Combinations of single-top-quark production cross-section measurements and |f_{LV}V_{tb}| determinations at \sqrt{s} = 7 and 8 TeV with the ATLAS and CMS experiments. JHEP, 2019, 05, pp.088. ⟨10.1007/JHEP05(2019)088⟩. ⟨hal-03171569⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for vector-like quarks in events with two oppositely charged leptons and jets in proton-proton collisions at \sqrt{s} = 13 TeV. Eur.Phys.J.C, 2019, 79 (4), pp.364. ⟨10.1140/epjc/s10052-019-6855-8⟩. ⟨hal-01975559⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for charged Higgs bosons in the H^{\pm} \to \tau^{\pm}\nu_\tau decay channel in proton-proton collisions at \sqrt{s} = 13 TeV. JHEP, 2019, 07, pp.142. ⟨10.1007/JHEP07(2019)142⟩. ⟨hal-02080696⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Observation of prompt J/\psi meson elliptic flow in high-multiplicity pPb collisions at \sqrt{s_\mathrm{NN}} = 8.16 TeV. Phys.Lett.B, 2019, 791, pp.172-194. ⟨10.1016/j.physletb.2019.02.018⟩. ⟨hal-01897241⟩

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