Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • M. Bedjidian. Quarkonia in CMS. CMS Heavy Ion Workshop 6, Feb 2002, Boston, United States. ⟨in2p3-00021839⟩
  • O. Lopez, G. Auger, C.O. Bacri, N. Bellaize, F. Bocage, et al.. What can be learned from central collisions around the Fermi energy. International Winter Meeting on Nuclear Physics 40, Jan 2002, Bormio, Italy. pp.188-197. ⟨in2p3-00011533⟩
  • H. Huebel, A.K. Singh, N. Nenoff, D. Rossbach, A. Goergen, et al.. Magnetic rotation in ^{196}Pb. International Winter Meeting on Nuclear Physics 40, Jan 2002, Bormio, Italy. pp.339-346. ⟨in2p3-00011538⟩
  • J.D. Frankland, A. Chbihi, S. Hudan, A. Mignon, A. Ono, et al.. Fragment production in central heavy-ion collisions: reconciling the dominance of dynamics with observed phase transition signals through universal fluctuations. International Winter Meeting on Nuclear Physics 40, Jan 2002, Bormio, Italy. pp.175-188. ⟨in2p3-00011353⟩
  • J.C. Steckmeyer, S. Aiello, A. Anazalone, G. Auger, M. Bini, et al.. Study of the dissipative binary channels in the ^{107}Ag + ^{58}Ni reaction at 52 MeV/nucleon. International Winter Meeting on Nuclear Physics 40, Jan 2002, Bormio, Italy. pp.198-208. ⟨in2p3-00011249⟩
  • M. Idzik, M.C. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, et al.. Pseudorapidity distributions of charged particles in Pb-Pb collisions at SPS energies from the NA50 experiment. International Winter Meeting on Nuclear Physics 40, Jan 2002, Bormio, Italy. pp.5-15. ⟨in2p3-00011530⟩
  • M. Buballa, M. Oertel. Color superconductivity in two and three flavor systems at moderate densities. NATO Advanced Research Workshop on Confinement Topology and other Non-Perturbative Aspects of QCD, Jan 2002, Stara Lesna, Slovakia. ⟨in2p3-00012027⟩
  • E. Galichet, B. Borderie, G. Lanzalone, M.F. Rivet, G. Auger, et al.. Study of isospin equilibration using Ni+Ni and Ni+Au peripheral collisions. International Winter Meeting on Nuclear Physics 40, Jan 2002, Bormio, Italy. pp.209-216. ⟨in2p3-00011535⟩
  • A. Buta, J.C. Steckmeyer, G. Auger, C.O. Bacri, N. Bellaize, et al.. Towards an unambiguous determination of the excitation energy of the projectile in heavy-ion reactions ?. International Winter Meeting on Nuclear Physics 40, Jan 2002, Bormio, Italy. pp.217-223. ⟨in2p3-00011248⟩
  • F. Prino, M-C. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, et al.. J/\psi production in proton-nucleus and nucleus-nucleus interactions at the CERN SPS. International Workshop on Gross Properties of Nuclei and Nuclear Excitations 30, Jan 2002, Hirschegg, Austria. pp.254-263. ⟨in2p3-00011439⟩

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