Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • D. Contardo. Etat de la construction du detecteur CMS. Journees d'Instrumentation et de Prospectives de l'IN2P3/DAPNIA, Jun 2002, Giens, France. ⟨in2p3-00021840⟩
  • S. Katsanevas, G. Largeron, J. Marteau, G. Moret. Auto-triggerable HPD sensors fully readout on Ethernet - applications for highs energy physics and medical imaging. New Development in Detection 3, Jun 2002, Beaune, France. pp.4. ⟨in2p3-00011886⟩
  • M. Ericson, G. Chanfray. Scalar and pseudoscalar QCD susceptibilities in nuclei. Conference on Quark Nuclear Physics QNP2002, Jun 2002, Juelich, Germany. pp.463-466. ⟨in2p3-00014157⟩
  • K. Bennaceur. Review of the shell model embedded in the continuum. Workshop on Continuum Aspects of the Nuclear Shell Model, Jun 2002, Trento, Italy. ⟨in2p3-00020156⟩
  • Ch. Eleftheriadis, S. Andriamonje, E. Arik, D. Autiero, F. Avignone, et al.. Axion searches at CERN with the CAST telescope. Greek Relativity Meeting on New Developments in Gravity (NEB X) 10, May 2002, Chalkidiki, Greece. pp.5. ⟨in2p3-00020267⟩
  • L. Chaussard. Long baseline neutrino experiments. Heavy Quarks and Leptons 2002 HQ&L 2002, May 2002, Vietri Sul Mare, Palerme, Italy. pp.427-435. ⟨in2p3-00012337⟩
  • B. Farizon, M. Farizon, M.J. Gaillard, F. Gobet, J.P. Buchet, et al.. Collision induced cluster fragmentation: From fragment size distributions to the caloric curve. 5th International Symposium on Swift Heavy Ions in Matter SHIM 2002, May 2002, Taormina, Italy. pp.9-18, ⟨10.1016/S0168-583X(02)02011-6⟩. ⟨in2p3-00013670⟩
  • C. Ray, F. Barrué, M. Chevallier, D. Dauvergne, R. Kirsch, et al.. Channeling of fast Pb^{56+} ions in a thin silicon crystal correlation between secondary electron emission energy loss and charge exchange. Conference Internationale Swift Heavy Ions in Matter SHIM 2002, May 2002, Taormina, Italy. 2002. ⟨in2p3-00011996⟩
  • A. Remillieux. Mirror coating R&D. Gravitational Wave Advanced Detector Workshop : Towards a Global Detection Network, May 2002, Elba, Italy. ⟨in2p3-00022325⟩
  • G. Chanfray. Hadrons in dense and hot matter and chiral symmetry restoration. Topical Workshop on the Nucleus-Nucleus Collision Research Program at the Future Facility of GSI, May 2002, Darmstadt, Germany. ⟨in2p3-00020274⟩

Powered by HAL logo