Health (PRISME)

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  • Activities
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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • D. Teyssier, P. Lebrun, G.-S. Muanza. Search for invisible Higgs boson decays in e^+e^- collisions at center-of-mass energies up to 209 GeV at LEP. International Conference on High Energy Physics 31, Jul 2002, Amsterdam, Netherlands. ⟨in2p3-00020293⟩
  • S. Gascon-Shotkin. Recent developments in Crystal calorimeter (featuring the CMS PbWO_4 electromagnetic calorimeter). 31st International Conference on High Energy Physics (ICHEP2002), Jul 2002, Amsterdam, Netherlands. ⟨in2p3-00024710⟩
  • P. Antilogus. Determination of AFBb using inclusive charge reconstruction and lifetime tagging at LEP1. International Conference on High Energy Physics (ICHEP 2002) 31, Jul 2002, Amsterdam, Netherlands. ⟨in2p3-00011997⟩
  • S. Katsanevas, P. Verdier. Search for an LSP gluino at LEP. International Conference on High Energy Physics (ICHEP 2002) 31, Jul 2002, Amsterdam, Netherlands. ⟨in2p3-00011998⟩
  • P. Cortese, C. Alexa, R. Arnaldi, M. Atayan, C. Baglin, et al.. Charmonia absorption in p-A collisions at the CERN SPS results and implications for Pb-Pb interactions. International Conference on Ultrarelativistic Nucleus Nucleus Collisions 16 Quark Matter 2002, Jul 2002, Nantes, France. pp.679c-682c. ⟨in2p3-00012334⟩
  • N.S. Topilskaya, B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, et al.. Transverse momentum distribution of J/\psi mesons produced in p-A and Pb-Pb interactions at the CERN SPS. International Conference on Ultrarelativistic Nucleus Nucleus Collisions 16 Quark Matter 2002, Jul 2002, Nantes, France. pp.675c-678c. ⟨in2p3-00012336⟩
  • L. Grandchamp, R. Rapp. Two-component approach to J/\psi production in high-energy heavy-ion collisions. Quark Matter 2002, Jul 2002, Nantes, France. pp.545-548. ⟨in2p3-00020166⟩
  • L. Ramello, C. Alexa, R. Arnaldi, M. Atayan, C. Baglin, et al.. Results on leptonic probes from NA50. International Conference on Ultrarelativistic Nucleus Nucleus Collisions 16 Quark Matter 2002, Jul 2002, Nantes, France. pp.243c-251c. ⟨in2p3-00012335⟩
  • S. Bongard. NLTE supernovae spectra simulation using PHOENIX. Supernovae Workshop on Type Ia Supernovae: Theory Meets Observations, Jul 2002, Leiden, Netherlands. ⟨in2p3-00024813⟩
  • S. Bongard. Simulation of supernovae. Workshop on Ia Supernovae, Jul 2002, Leiden, Netherlands. ⟨in2p3-00011993⟩

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