Health (PRISME)

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  • Activities
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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • S. Andriamonje, E. Arik, D. Autiero, F. Avignone, K. Barth, et al.. CAST: a search for solar axions at CERN. Conference on Astronomical Telescopes and Instrumenation, Aug 2002, Waikoloa, United States. pp.5. ⟨in2p3-00020268⟩
  • M. Lampton, C. Bebek, C.W. Akerlof, G. Aldering, R. Amanullah, et al.. SNAP telescope. SPIE'S Astronomical Telescopes and Instrumentation, Aug 2002, Waikoloa, United States. pp.215-226. ⟨in2p3-00020392⟩
  • P. Di Stefano. New limits from the EDELWEISS experiment. Conference on the New Cosmology Confronts Observation, Aug 2002, Santa Barbara, United States. ⟨in2p3-00020214⟩
  • H. Hubel, A.K. Singh, N. Nenoff, D. Rossbach, A. Gorgen, et al.. Magnetic rotation in ^{196}Pb. Conference on Frontiers of Nuclear Structure, Jul 2002, Berkeley, United States. pp.184-189. ⟨in2p3-00013939⟩
  • E. Pécontal, G. Aldering, G. Adam, P. Antilogus, P. Astier, et al.. The Nearby Supernova Factory. Proceedings of the ESO/MPA/MPE Workshop, Jul 2002, Garching, Germany. pp.404. ⟨in2p3-00024775⟩
  • E. Pecontal, G. Aldering, G. Adam, P. Antilogus, P. Astier, et al.. The nearby supernova factory. ESO/MPA/MPE Workshop, Jul 2002, Garching, Germany. ⟨in2p3-00020376⟩
  • C. Quintans, B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, et al.. New results on J/\psi from NA50 experiment. International Conference on High Energy Physics 31 ICHEP 2002, Jul 2002, Amsterdam, Netherlands. pp.68-70, ⟨10.1016/S0920-5632(03)90490-7⟩. ⟨in2p3-00012891⟩
  • S. Katsanevas, P. Verdier. Search for an LSP gluino at LEP. International Conference on High Energy Physics (ICHEP 2002) 31, Jul 2002, Amsterdam, Netherlands. ⟨in2p3-00011998⟩
  • J. Abdallah, P. Abreu, W. Adam, P. Adzic, T. Albrecht, et al.. b-tagging in DELPHI at LEP. International Conference on High Energy Physics (ICHEP 2002) 31, Jul 2002, Amsterdam, Netherlands. pp.1-12. ⟨in2p3-00012576⟩
  • D. Teyssier, P. Lebrun, G.-S. Muanza. Search for invisible Higgs boson decays in e^+e^- collisions at center-of-mass energies up to 209 GeV at LEP. International Conference on High Energy Physics 31, Jul 2002, Amsterdam, Netherlands. ⟨in2p3-00020293⟩

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