Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • B. Farizon, M. Farizon, M.J. Gaillard, F. Gobet, J.P. Buchet, et al.. Collision induced fragmentation of hydrogen cluster and phase transition. Workshop ECCN2002 Delayed Ionisation and Computing Cooling Mechanisms in Atomic Clusters, Sep 2002, Strasbourg, France. ⟨in2p3-00011977⟩
  • B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, C. Baglin, et al.. Recent results of J/\psi suppression from the NA50 experiment at CERN SPS. International Conference on Quark Confinement and the Hadron Spectrum 5, Sep 2002, Gargnano, Italy. pp.456-458. ⟨in2p3-00020131⟩
  • M. Fallavier, R. Kirsch, S.N. Mozorov, J.-C. Poizat, J.-P. Thomas, et al.. Intense emission of cluster anions from gold targets under impact of keV/u gold clusters. 11th International Symposium on Small Particles and Inorganic Clusters, Sep 2002, Strasbourg, France. pp.14. ⟨in2p3-00013969⟩
  • D. Dauvergne, A. Brauening-Demian, F. Bosch, H. Brauening, M. Chevallier, et al.. Impact parameter dependent electron capture by decelerated U^{91+} ions at 20 MeV/u using crystal channeling conditions. International Conference on Highly Charged Ions, Sep 2002, Caen, France. pp.773. ⟨in2p3-00013680⟩
  • D. Drain. Latest results of the EDELWEISS experiment. International Workshop on the Identification of Dark Matter - IDM02, Sep 2002, York, United Kingdom. ⟨in2p3-00020218⟩
  • R. Flaminio, F. Bellachia, D. Boget, D. Buskulic, François Chollet, et al.. The gravitational wave detector VIRGO. Advanced ICFA Beam Dynamics Workshop on Nanometre Size Colliding Beams 26 Nanobeam 2002, Sep 2002, Lausanne, Switzerland. pp.7-13. ⟨in2p3-00013993⟩
  • J. Remillieux, M. Bajard. Hadrontherapie par faisceaux d'ions legers : - le projet ETOILE. Ecole d'Ete de Physique e2phy 2002, Aug 2002, Villeurbanne, France. pp.191-215. ⟨in2p3-00013835⟩
  • A. Ealet, A. Bonissent, R. Malina, G.M. Bernstein, S. Basa, et al.. An Integral Field Spectrograph for SNAP Supernova Identification. IR Space Telescopes and Instruments, Aug 2002, Waikoloa, United States. pp.1169-1178, ⟨10.1117/12.461216⟩. ⟨in2p3-00020388⟩
  • A. Ealet, C. Bebek, C.W. Akerlof, G. Aldering, R. Amanullah, et al.. The SNAP spectrograph. SPIE'S Astronomical Telescopes and Instrumentation, Aug 2002, Waikoloa, United States. ⟨in2p3-00020443⟩
  • S. Andriamonje, E. Arik, D. Autiero, F. Avignone, K. Barth, et al.. CAST: a search for solar axions at CERN. Conference on Astronomical Telescopes and Instrumenation, Aug 2002, Waikoloa, United States. pp.5. ⟨in2p3-00020268⟩

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