Health (PRISME)

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  • Activities
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  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • Ketel Turzo. Study of the 12C+197Au reaction at relativistic energies with the INDRA 4pi multidetector. Nuclear Theory [nucl-th]. Université Claude Bernard - Lyon I, 2002. English. ⟨NNT : ⟩. ⟨tel-00002954⟩
  • B. Trocme. The CMS tracker 2002 text beam at PSI. Vertex Detectors 11, Nov 2002, Kailua-Koan, United States. pp.187-189. ⟨in2p3-00014021⟩
  • A. Brunelle, S. Bouneau, S. Della Negra, J. Depauw, Y. Le Beyec, et al.. Sputtering and secondary ion emission induced by gold clusters: - Energy and angular distributions. Conference on Desorption 2002, Nov 2002, Estes Park, United States. ⟨in2p3-00014262⟩
  • J. Gascon. Identification de la Matiere Noire (Prospectives). Journees d'Instrumentation et de Prospectives de l'IN2P3, Oct 2002, Giens, France. ⟨in2p3-00020213⟩
  • M. Cappellari, R. C. E. van Den Bosch, E. K. Verolme, R. Bacon, M. Bureau, et al.. Dynamical Modeling of SAURON Galaxies. Carnegie Observatoires Centennial Symposia, Oct 2002, Pasadena, United States. ⟨in2p3-00024773⟩
  • Hubert Hansen. Méthodes non-perturbatives en théorie quantique des champs. Au-delà du champ moyen, l'approximation de la phase aléatoire.. Physique mathématique [math-ph]. Université Claude Bernard - Lyon I, 2002. Français. ⟨NNT : ⟩. ⟨tel-00003814⟩
  • Y. Copin. The nearby supernova factory. Colloque Programme National de Cosmologie, Oct 2002, Paris, France. ⟨in2p3-00020368⟩
  • A. Deandrea, G. Nardulli, A.D. Polosa. A note on the J/\psi strong couplings. Workshop on Hard Probes in Heavy Ion Collisions at the LHC, Oct 2002, Geneve, Switzerland. pp.10. ⟨in2p3-00012050⟩
  • L. Pinard. Towards better optics. Meeting GDR GREX (Gravitation and Experiment) 2002, Oct 2002, Pise, Italy. ⟨in2p3-00012008⟩
  • J.-F. Parriaud. Measurement of the \bar{p}/p ratio in cosmic rays using the moon shadow with the L3+C detector. Rencontres de Blois, Oct 2002, Blois, France. pp.4. ⟨in2p3-00011966⟩

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