Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • R. Arnaldi, G. Usai, K. Banicz, K. Borer, J. Buytaert, et al.. First results from the NA60 experiment at CERN. Rencontres de Moriond on QCD and High-Energy Hadronic Interactions 38, 2003, Les Arcs, France. pp.4. ⟨in2p3-00014136⟩
  • G.-S. Muanza. Recherche de la SUSY au TEVATRON - Etat actuel. Reunion francaise de l'Euro-GDR SUSY, Dec 2002, Montpellier, France. ⟨in2p3-00020288⟩
  • Imad Laktineh. Une synthèse des travaux de recherche sur la supersymétrie et le neutrino. Cosmologie et astrophysique extra-galactique [astro-ph.CO]. Université Claude Bernard - Lyon I, 2002. ⟨tel-00006865⟩
  • Aziz Rabhi. Approximation des phases aléatoires self-consistante dans l'étude de la superfluidité des systèmes fermioniques. Physique mathématique [math-ph]. Université Claude Bernard - Lyon I, 2002. Français. ⟨NNT : ⟩. ⟨tel-00003303⟩
  • L. Chabert. Etude du veto muon pour l'experience EDELWEISS II. Journees Jeunes Chercheurs 2002, Dec 2002, Aussois, France. ⟨in2p3-00020216⟩
  • J.L. Boldo, C.P. Constantinidis, F. Gieres, M. Lefrançois, O. Piguet. Topological Yang-Mills theories and their observables: a superspace approach. Winter School Mathematical Methods in Physics 2002 2, Dec 2002, Londrina, Brazil. pp.2119-2126. ⟨in2p3-00013729⟩
  • N. Chevarier. Analyse par faisceaux d'ions : principe performances et limites. Colloque sur les Spectroscopies de la Physique a la Caracterisation des Materiaux, Nov 2002, Lyon, France. ⟨in2p3-00020197⟩
  • A. Szanto de Toledo, E.E. Alonso, N. Carlin, R. Liguori Neto, M.M. Moura, et al.. Fusion of light weakly bound nuclei. International Symposium on Physics of Unstable Nuclei ISPUN 2002, Nov 2002, Halong Bay, Vietnam. pp.248c-253c. ⟨in2p3-00013991⟩
  • M. Fallavier, R. Kirsch, J.-C. Poizat, J.-P. Thomas, N. Wehbe. Caracteristiques de l'emission secondaire d'agregats negatifs induite sur des cibles d'or par des faisceaux d'or: Effets de taille dans le domaine d'energie de la centaine de keV/atome. Journees Francaises de Spectrometrie de Masse 19, Nov 2002, Chaville, France. ⟨in2p3-00020143⟩
  • M. Fallavier, R. Kirsch, S.N. Morozov, J.-C. Poizat, J.-P. Thomas. Intense cluster ion emission from gold targets under the impact of MeV Au^+_n clusters. International Symposium on Small Particles and Inorganic Clusters 11, Nov 2002, Strasbourg, France. 2002. ⟨in2p3-00014261⟩

Powered by HAL logo