The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

8787 documents

  • C. Borges, B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, et al.. Latest results on J/\psi suppression. Winter Workshop on Nuclear Dynamics 19, 2003, Breckenridge, United States. ⟨in2p3-00014145⟩
  • A. Deandrea, G. Nardulli, A.D. Polosa. Mass of the D_s(0^+, 1^+) system. Physical Review D, 2003, 68, pp.097501. ⟨in2p3-00013802⟩
  • S. Gavarini, B. Boizot, F. Carrot, P. Trocelliera, G. Matzen. Dissolution of LnYSiAlO glass (Ln=La or Ce) in aqueous media. III. Influence of \beta irradiation on structure and hydrolysis mechanisms. Journal of Non-Crystalline Solids, 2003, 332, pp.141-152. ⟨10.1016/j.jnoncrysol.2003.09.034⟩. ⟨in2p3-00024616⟩
  • X. Artru, S.P. Fomin, N.F. Shul'Ga. Special features of the angular distribution of radiation by relativistic electrons in a thin crystal. International Workshop on Radiation by Relativistic Electrons in Periodic Structures 6, 2003, Tomsk, Russia. ⟨in2p3-00014239⟩
  • E. Elbaz. Quantum cosmology with the use of (F.R.W) equations. Salim J.M. Inquiring the universe Essays to celebrate Professor Mario Novello jubilee, Frontier Group, pp.279-287, 2003. ⟨in2p3-00014232⟩
  • Y. Lallouet, D. Davesne, C. Pujol. Hydrodynamics with spontaneous symmetry breaking: application to relativistic heavy ion collisions. Physical Review C, 2003, 67, pp.057901-1-057901-4. ⟨10.1103/PhysRevC.67.057901⟩. ⟨in2p3-00012711⟩
  • R. Arnaldi, K. Banicz, K. Borer, J. Buytaert, J. Castor, et al.. The NA60 experiment - First results and prospects. International Workshop on QCD, 2003, Conversano, Italy. pp.5. ⟨in2p3-00014137⟩
  • W. Adam, W. Beaumont, V. Zhukov, D. Contardo, N. Lumb, et al.. Test beam analysis of the effect of highly ionising particles on the silicon strip tracker. 2003, pp.41. ⟨in2p3-00020330⟩
  • P. Depasse, M. Goyot. Etude d'une matrice de photodiodes a avalanche associee a des cristaux scintillants (LSO et LuAP). 2003, pp.23. ⟨in2p3-00014122⟩
  • J. Abdallah, P. Abreu, W. Adam, P. Adzic, T. Albrecht, et al.. A measurement of the branching fractions of the b-quarks into charged and neutral b-hadrons. Physics Letters B, 2003, 576, pp.29-42. ⟨10.1016/j.physletb.2003.09.070⟩. ⟨in2p3-00021584⟩