Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • D. Davesne, M. Oertel, H. Hansen. A consistent approximation scheme beyond RPA for bosons. The European physical journal. A, Hadrons and Nuclei, 2003, 16, pp.35-42. ⟨10.1140/epja/i2002-10075-y⟩. ⟨in2p3-00012266⟩
  • P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, G. Alemanni, et al.. Measurement of W polarisation at LEP. Physics Letters B, 2003, 557, pp.147-156. ⟨10.1016/S0370-2693(03)00172-2⟩. ⟨in2p3-00012561⟩
  • M. Baldo, M. Buballa, G. F. Burgio, F. Neumann, M. Oertel, et al.. Neutron stars and the transition to color-superconducting quark matter. Physics Letters B, 2003, 562, pp.153-160. ⟨hal-00012781⟩
  • P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, G. Alemanni, et al.. Study of the e^{+}e^{-}\to Ze^{+}e^{-} Process at LEP. Physics Letters B, 2003, 561, pp.73-81. ⟨10.1016/S0370-2693(03)00406-4⟩. ⟨in2p3-00012560⟩
  • Pierre-Frédéric Villard, Michaël Beuve, Behzad Shariat, Vincent Baudet, Fabrice Jaillet, et al.. Continous Media Mechanics simulation of Lung Motion.. 9th workshop on Heavy Charged Particles in Biology and Medicine, 2003, Lyon, France. ⟨hal-00849210⟩
  • K.A. Assamagnan, A. Deandrea, P.-A. Delsart. Search for the lepton flavor violating decay A^0/H^0 \to \tau^\pm \mu^\mp at hadron colliders. Physical Review D, 2003, 67, pp.035001. ⟨in2p3-00013645⟩
  • E. Bellotti, Y. Déclais, P. Strolin, L. Zanotti. Neutrino physics. International School of Physics on Neutrino Physics 152, Jul 2002, Varenna, Italy. Ios Press, pp.304, 2003, International School Of Physics Enrico Fermi. ⟨in2p3-00020419⟩
  • M. Cappellari, Y. Copin. Adaptative spatial binning of integral field spectroscopic data using Voronoi tessellations. Monthly Notices of the Royal Astronomical Society, 2003, 342, pp.345-354. ⟨10.1046/j.1365-8711.2003.06541.x⟩. ⟨in2p3-00019946⟩
  • J. Meyer. Interactions effectives theories de champ moyen masses et rayons nucleaire Effective interactions, mean field theories, masses and nuclear radii. Annales de Physique, 2003, 28, pp.1-112. ⟨10.1051/anphys:2003006⟩. ⟨in2p3-00014243⟩
  • P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, G. Alemanni, et al.. Measurement of exclusive \rho^0 \rho^0 production in two-photon collisions at high Q^2 at LEP. Physics Letters B, 2003, 568, pp.11-22. ⟨10.1016/j.physletb.2003.05.003⟩. ⟨in2p3-00013949⟩

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