Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, et al.. Charged jet cross section and fragmentation in proton-proton collisions at \sqrt{s} = 7 TeV. Physical Review D, 2019, 99 (1), pp.012016. ⟨10.1103/PhysRevD.99.012016⟩. ⟨hal-01880834⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for long-lived particles using delayed photons in proton-proton collisions at \sqrt{s}= 13 TeV. Phys.Rev.D, 2019, 100 (11), pp.112003. ⟨10.1103/PhysRevD.100.112003⟩. ⟨hal-02317356⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for a low-mass \tau^+\tau^- resonance in association with a bottom quark in proton-proton collisions at \sqrt{s}= 13 TeV. JHEP, 2019, 05, pp.210. ⟨10.1007/JHEP05(2019)210⟩. ⟨hal-02165527⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Inclusive search for supersymmetry in pp collisions at \sqrt{s}=13 TeV using razor variables and boosted object identification in zero and one lepton final states. JHEP, 2019, 03, pp.031. ⟨10.1007/JHEP03(2019)031⟩. ⟨hal-01975261⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for invisible decays of a Higgs boson produced through vector boson fusion in proton-proton collisions at \sqrt{s} = 13 TeV. Phys.Lett.B, 2019, 793, pp.520-551. ⟨10.1016/j.physletb.2019.04.025⟩. ⟨hal-01886179⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurements of triple-differential cross sections for inclusive isolated-photon+jet events in pp collisions at \sqrt{s} = 8\,\text {TeV}. Eur.Phys.J.C, 2019, 79 (11), pp.969. ⟨10.1140/epjc/s10052-019-7451-7⟩. ⟨hal-02277872⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Measurement of the top quark Yukawa coupling from \mathrm{t\bar{t}} kinematic distributions in the lepton+jets final state in proton-proton collisions at \sqrt{s} = 13 TeV. Phys.Rev.D, 2019, 100 (7), pp.072007. ⟨10.1103/PhysRevD.100.072007⟩. ⟨hal-02188876⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Performance of missing transverse momentum reconstruction in proton-proton collisions at \sqrt{s} = 13 TeV using the CMS detector. JINST, 2019, 14 (07), pp.P07004. ⟨10.1088/1748-0221/14/07/P07004⟩. ⟨hal-02080718⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Jet Shapes of Isolated Photon-Tagged Jets in Pb-Pb and pp Collisions at \sqrt{s_\mathrm{NN}} = 5.02 TeV. Phys.Rev.Lett., 2019, 122 (15), pp.152001. ⟨10.1103/PhysRevLett.122.152001⟩. ⟨hal-01890845⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. An embedding technique to determine \tau\tau backgrounds in proton-proton collision data. JINST, 2019, 14 (06), pp.P06032. ⟨10.1088/1748-0221/14/06/P06032⟩. ⟨hal-02073514⟩

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